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Regular Aspirin Intake and Acute Myocardial Infarction

Overview
Journal Br Med J
Specialty General Medicine
Date 1974 Mar 9
PMID 4816857
Citations 11
Affiliations
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Abstract

The results of two large independent studies involving a combined total of 776 patients treated in hospital with a discharge diagnosis of acute myocardial infarction and 13,898 patients with other discharge diagnoses showed a negative association between regular aspirin intake and non-fatal myocardial infarction. The data are consistent with the hypothesis that aspirin protects against this disease. Clinical trials are needed to determine whether this hypothesis is correct.

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References
1.
Weiss H, Aledort L, Kochwa S . The effect of salicylates on the hemostatic properties of platelets in man. J Clin Invest. 1968; 47(9):2169-80. PMC: 297378. DOI: 10.1172/JCI105903. View
2.
Weiss H, Aledort L . Impaired platelet-connective-tissue reaction in man after aspirin ingestion. Lancet. 1967; 2(7514):495-7. DOI: 10.1016/s0140-6736(67)91658-3. View
3.
Jones B, Leeton J, McLeod I, Wood C . Factors influencing the age of menarche in a lower socio-economic group in Melbourne. Med J Aust. 1972; 2(10):533-5. DOI: 10.5694/j.1326-5377.1972.tb47460.x. View
4.
Mantel N, Haenszel W . Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959; 22(4):719-48. View
5.
Elwood P, Cochrane A, Burr M, Sweetnam P, Williams G, Welsby E . A randomized controlled trial of acetyl salicylic acid in the secondary prevention of mortality from myocardial infarction. Br Med J. 1974; 1(5905):436-40. PMC: 1633246. DOI: 10.1136/bmj.1.5905.436. View