Myocardial Inactivity of Therapeutic Concentrations of Hydralazine and Diazoxide

Overview

Journal Experientia

Specialty Science

Date 1974 Feb 15

PMID 4814601

Citations 3

Authors

J Koch-Weser

Affiliations

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Citing Articles

Cardiovascular effects of alinidine and propranolol alone and in combination with hydralazine in normal man.

Nicholls D, Harron D, Shanks R Br J Clin Pharmacol. 1983; 15(1):21-9.

PMID: 6849740 PMC: 1427818. DOI: 10.1111/j.1365-2125.1983.tb01458.x.

Haemodynamic effects of hydrallazine and of hydrallazine plus glyceryl trinitrate paste in heart failure.

Mehta J, Pepine C, Conti C Br Heart J. 1978; 40(8):845-50.

PMID: 99155 PMC: 483497. DOI: 10.1136/hrt.40.8.845.

Antihypertensive drugs: clinical pharmacology and therapeutic use.

Wollam G, GIFFORD Jr R, TARAZI R Drugs. 1977; 14(6):420-60.

PMID: 23284 DOI: 10.2165/00003495-197714060-00002.

References

Koch-Weser J . Vasodilation for vasospastic hypertension. N Engl J Med. 1973; 289(4):213-4. DOI: 10.1056/NEJM197307262890411. View

Stunkard A, WERTHEIMER L, Redisch W . Studies on hydralazine; evidence for a peripheral site of action. J Clin Invest. 1954; 33(7):1047-53. PMC: 438540. DOI: 10.1172/JCI102972. View

Rubin A, ROTH F, Taylor R, ROSENKILDE H . Pharmacology of diazoxide, an antihypertensive, nondiuretic benzothiadiazine. J Pharmacol Exp Ther. 1962; 136:344-52. View

Sellers E, Koch-Weser J . Protein binding and vascular activity of diazoxide. N Engl J Med. 1969; 281(21):1141-5. DOI: 10.1056/NEJM196911202812102. View

Zacest R, Koch-Weser J . Relation of hydralazine plasma concentration to dosage and hypotensive action. Clin Pharmacol Ther. 1972; 13(3):420-5. DOI: 10.1002/cpt1972133420. View

FREIS E . HYDRALAZINE IN HYPERTENSION. Am Heart J. 1964; 67:133-4. DOI: 10.1016/0002-8703(64)90408-9. View

Rubin A, ZITOWITZ L, HAUSLER L . Acute circulatory effects of diazoxide and sodium nitrite. J Pharmacol Exp Ther. 1963; 140:46-51. View

Dahr A, George C, Dollery C . The effect of selective cardiac adrenergic beta-blockade on the hypotensive effect of hydrallazine. Experientia. 1971; 27(5):545-6. DOI: 10.1007/BF02147591. View

Gershwin M, Smith N . Mode of action of hydralazine on guinea pig atria. Arch Int Pharmacodyn Ther. 1967; 170(1):108-16. View

10.

Markis J, Koch-Weser J . Characteristics and mechanism of inotropic and chronotropic actions of bretylium tosylate. J Pharmacol Exp Ther. 1971; 178(1):94-102. View

11.

Koch-Weser J, BLINKS J . THE INFLUENCE OF THE INTERVAL BETWEEN BEATS ON MYOCARDIAL CONTRACTILITY. Pharmacol Rev. 1963; 15:601-52. View

12.

Zacest R, Gilmore E, Koch-Weser J . Treatment of essential hypertension with combined vasodilation and beta-adrenergic blockade. N Engl J Med. 1972; 286(12):617-22. DOI: 10.1056/NEJM197203232861201. View

13.

Finnerty Jr F, KAKAVIATOS N, Tuckman J, Magill J . CLINICAL EVALUATION OF DIAZOXIDE: A NEW TREATMENT FOR ACUTE HYPERTENSION. Circulation. 1963; 28:203-8. DOI: 10.1161/01.cir.28.2.203. View

14.

Koch-Weser J . Effect of rate changes on strength and time course of contraction of papillary muscle. Am J Physiol. 1963; 204:451-7. DOI: 10.1152/ajplegacy.1963.204.3.451. View

15.

Ablad B . A study of the mechanism of the hemodynamic effects of hydralazine in man. Acta Pharmacol Toxicol (Copenh). 1963; 20(Suppl 1):1-53. View

16.

Koch-Weser J . Beta-receptor blockade and myocardial effects of cardiac glycosides. Circ Res. 1971; 28(2):109-18. DOI: 10.1161/01.res.28.2.109. View