Role of Virus Variants and Cells in Maintenance of Persistent Infection by Measles Virus

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1979 Apr 1

PMID 480462

Citations 4

Authors

L E Fisher

F Rapp

Affiliations

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Abstract

Hamster embryo fibroblasts persistently infected with a derivative of the Schwarz vaccine strain of measles virus spontaneously released virus particles with an average buoyant density considerably lower than that of the parental virus. The released virus contained all of the measles virus structural proteins and interfered with replication of standard virus. All of the virus structural proteins were associated with a membrane-free cytoplasmic extract from the persistently infected cells. Membrane-free cytoplasmic extracts prepared from Vero cells lytically infected with Schwarz strain measles contained little or no virus envelope structural protein. Maintenance of persistent infection may involve both the presence of virus variants and a defect in the ability of the infected cell to replicate the virus efficiently.

Citing Articles

Measles virus induces persistent infection by autoregulation of viral replication.

Doi T, Kwon H, Honda T, Sato H, Yoneda M, Kai C Sci Rep. 2016; 6:37163.

PMID: 27883010 PMC: 5121633. DOI: 10.1038/srep37163.

Measles virus: evolution of a persistent infection in BGM cells.

Wild T, Bernard A, Greenland T Arch Virol. 1981; 67(4):297-308.

PMID: 7236013 DOI: 10.1007/BF01314833.

Characterization of four cell lines persistently infected with measles virus.

Fisher L Arch Virol. 1983; 77(1):51-60.

PMID: 6354137 DOI: 10.1007/BF01314863.

Isolation of cold-sensitive mutants of measles virus from persistently infected murine neuroblastoma cells.

Rager-Zisman B, Egan J, Kress Y, Bloom B J Virol. 1984; 51(3):845-55.

PMID: 6206237 PMC: 255853. DOI: 10.1128/JVI.51.3.845-855.1984.

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