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» Articles » PMID: 478539

Chromosome Lesions in Amniotic Fluid Cell Cultures

Overview
Journal Hum Genet
Specialty Genetics
Date 1979 Jul 18
PMID 478539
Authors
G Simoni
L Larizza
N Sacchi
G Della Valle
F DAmbrosio
L De Carli
Affiliations
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Abstract

The frequencies of chromosome lesions were determined on 3537 mitoses in samples of varying sizes from cultures of 25 amniotic fluid specimens taken from patients at cytogenetic risk. The average percentage values of aberrant cells, including and excluding gaps, were 12.5 and 4.9, respectively. The corresponding values for fibroblasts and peripheral blood lymphocytes from normal adult donors, calculated under the same laboratory conditions, were 5.0 (including gaps) and 2.4 (excluding gaps) and 2.4 (including gaps) and 1.0 (excluding gaps), respectively. The hypothesis of a correlation between the increased incidence of chromosome lesions and the occurrence of abnormal karyotypes in amniotic fluid cell cultures is discussed.

References
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