Pattern of Growth Hormone Response to Insulin, Arginine and Haemodialysis in Uraemic Children

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 1979 Jun 28

PMID 477677

Citations 3

Authors

K Ijaiya

Affiliations

Soon will be listed here.

Abstract

Plasma growth hormone (GH) concentrations after insulin and arginine stimulation were estimated in 11 dialyzed and 6 non-dialyzed children with chronic renal failure. Twenty healthy children served as controls. Plasma GH peak concentration and estimation of the total area under the plasma GH concentration-time curve by the trapezoidal rule were used to evaluate results. Elevated basal GH levels and an exaggerated response to the stimuli were seen in several of the patients. The causes of the abnormal GH secretion and the role of high GH levels in carbohydrate intolerance are discussed. No consistent pattern was seen in GH secretion during haemodialysis without glucose in the dialysate. In children undergoing haemodialysis with a fluid containing glucose, plasma GH fell considerably.

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References

Cowden E, Ratcliffe W, Ratcliffe J, Dobbie J, Kennedy A . Hyperprolactinaemia in renal disease. Clin Endocrinol (Oxf). 1978; 9(3):241-8. DOI: 10.1111/j.1365-2265.1978.tb02206.x. View

KAHIL M, PARRISH J, Simons E, Brown H . Magnesium deficiency and carbohydrate metabolism. Diabetes. 1966; 15(10):734-9. DOI: 10.2337/diab.15.10.734. View

KOKOT F, KUSKA J . Influence of extracorporeal dialysis on glucose utilization and insulin secretion in patients with acute renal failure. Eur J Clin Invest. 1973; 3(2):105-11. DOI: 10.1111/j.1365-2362.1973.tb00336.x. View

Cohen B . Abnormal carbohydrate metabolism in renal disease. Blood glucose unresponsiveness to hypoglycemia, epinephrine, and glucagon. Ann Intern Med. 1962; 57:204-13. DOI: 10.7326/0003-4819-57-2-204. View

Fish J, REMMERS Jr A, Lindley J, SARLES H . Albumin kinetics and nutritional rehabilitation in the unattended home-dialysis patient. N Engl J Med. 1972; 287(10):478-81. DOI: 10.1056/NEJM197209072871002. View

Cerletty J, ENGBRING N . Azotemia and glucose intolerance. Ann Intern Med. 1967; 66(6):1097-108. DOI: 10.7326/0003-4819-66-6-1097. View

Simmons J, Wilson C, Potter D, HOLLIDAY M . Relation of calorie deficiency to growth failure in children on hemodialysis and the growth response to calorie supplementation. N Engl J Med. 1971; 285(12):653-6. DOI: 10.1056/NEJM197109162851203. View

RUBENFELD S, Garber A . Abnormal carbohydrate metabolism in chronic renal failure. The potential role of accelerated glucose production, increased gluconeogenesis, and impaired glucose disposal. J Clin Invest. 1978; 62(1):20-8. PMC: 371732. DOI: 10.1172/JCI109107. View

PIMSTONE B, BARBEZAT G, Hansen J, Murray P . Growth hormone and protein-calorie malnutrition. Impaired suppression during induced hyperglycaemia. Lancet. 1967; 2(7530):1333-4. DOI: 10.1016/s0140-6736(67)90916-6. View

10.

Feldman H, Singer I . Endocrinology and metabolism in uremia and dialysis: a clinical review. Medicine (Baltimore). 1975; 54(5):345-76. DOI: 10.1097/00005792-197509000-00001. View

11.

Linder G, Hiller A, VAN SLYKE D . CARBOHYDRATE METABOLISM IN NEPHRITIS. J Clin Invest. 1925; 1(3):247-72. PMC: 434553. DOI: 10.1172/JCI100014. View

12.

Sherwin R, Bastl C, Finkelstein F, Fisher M, Black H, Hendler R . Influence of uremia and hemodialysis on the turnover and metabolic effects of glucagon. J Clin Invest. 1976; 57(3):722-31. PMC: 436707. DOI: 10.1172/JCI108330. View

13.

Whitehead R, DEAN R . SERUM AMINO ACIDS IN KWASHIORKOR. I. RELATIONSHIP TO CLINICAL CONDITION. Am J Clin Nutr. 1964; 14:313-9. DOI: 10.1093/ajcn/14.6.313. View

14.

Lowrie E, Soeldner J, HAMPERS C, MERRILL J . Glucose metabolism and insulin secretion in uremic, prediabetic, and normal subjects. J Lab Clin Med. 1970; 76(4):603-15. View

15.

Bindeballe W, Drenkhahn E, Jusgen W, Lahrtz H, LEYBOLD K, NIEDERMAYER W . [Influence of hemodialysis on hormone levels in preterminal renal failure]. Dtsch Med Wochenschr. 1973; 98(13):661-5. DOI: 10.1055/s-0028-1106879. View

16.

Rabkin R, Pimstone B, Marks T, EALES L . Disappearnace of human growth hormone 125 I in the anephric non-uraemic and uraemic rat. Horm Metab Res. 1972; 4(6):467-9. DOI: 10.1055/s-0028-1094007. View

17.

Hicks J, Young D, Wootton I . THE EFFECT OF URAEMIC BLOOD CONSTITUENTS ON CERTAIN CEREBRAL ENZYMES. Clin Chim Acta. 1964; 9:228-35. DOI: 10.1016/0009-8981(64)90099-3. View

18.

Orskov H, Christensen N . Growth hormone in uremia. I. Plasma growth hormone, insulin and glucagon after oral and intravenous glucose in uremic subjects. Scand J Clin Lab Invest. 1971; 27(1):51-60. DOI: 10.3109/00365517109080189. View

19.

Perlroth M, TSCHUDY D, Waxman A, Odell W . Abnormalities of growth hormone regulation in acute intermittent porphyria. Metabolism. 1967; 16(1):87-90. DOI: 10.1016/0026-0495(67)90163-1. View

20.

WEST C, Smith W . An attempt to elucidate the cause of growth retardation in renal disease. AMA J Dis Child. 1956; 91(5):460-76. DOI: 10.1001/archpedi.1956.02060020462008. View