Effects of Discontinuation of Chronic Feeding of Diethylnitrosamine on the Development of Hepatomas in Adult Rats

Overview

Journal Br J Cancer

Specialty Oncology

Date 1979 Aug 1

PMID 475971

Citations 1

Authors

H Barbason

V SMOLIAR

E H BETZ

Affiliations

Soon will be listed here.

Abstract

Diethylnitrosamine (DENA) at 10 mg/kg was fed to adult rats either continuously or for periods ranging from 1 to 10 weeks. Survival correlated inversely with the duration of carcinogen feeding. Less than 4 weeks of DENA feeding produced only preneoplastic foci that persisted indefinitely; 4 weeks were found to be necessary for the transformation of preneoplastic lesions into liver cancers; after 6 weeks, the incidence of hepatomas was 100%. The process of liver cancerization appeared to be identical whether DENA was fed for 8 weeks or continuously up to the time of death. These results are discussed in the light of the evolution of the homoeostatic control of liver-cell division during DENA feeding, in order to distinguish the different successive roles played by the carcinogen.

Citing Articles

Promotion mechanism of phenobarbital and partial hepatectomy in DENA hepatocarcinogenesis cell kinetics effect.

Barbason H, Rassenfosse C, BETZ E Br J Cancer. 1983; 47(4):517-25.

PMID: 6849796 PMC: 2011340. DOI: 10.1038/bjc.1983.82.

References

Pitot H . The stability of events in the natural history of neoplasia. Am J Pathol. 1977; 89(3):703-16. PMC: 2032262. View

Williams G, Klaiber M, Farber E . Differences in growth of transplants of liver, liver hyperplastic nodules, and hepatocellular carcinomas in the mammary fat pad. Am J Pathol. 1977; 89(2):379-90. PMC: 2032237. View

Barbason H, LELIEVRE P, BETZ E . Variations of liver cell control during diethylnitrosamine carcinogenesis. Eur J Cancer (1965). 1977; 13(1):13-8. DOI: 10.1016/0014-2964(77)90223-7. View

Farber E, Solt D, Cameron R, Laishes B, Ogawa K, Medline A . Newer insights into the pathogenesis of liver cancer. Am J Pathol. 1977; 89(2):477-82. PMC: 2032235. View

Scherer E, Hoffmann M . Probable clonal genesis of cellular islands induced in rat liver by diethylnitrosamine. Eur J Cancer (1965). 1971; 7(4):369-71. DOI: 10.1016/0014-2964(71)90083-1. View

Scherer E, Hoffmann M, Emmelot P, Friedrich-Freksa M . Quantitative study on foci of altered liver cells induced in the rat by a single dose of diethylnitrosamine and partial hepatectomy. J Natl Cancer Inst. 1972; 49(1):93-106. View

Ogawa K, Kaneko A, Minase T, Onoe T . Persistent changes induced by subcarcinogenic doses of 3'-methyl-4-(dimethylamino)azobenzene in rat liver. Gan. 1974; 65(2):109-17. View

Hughes P . Liver cell responses to the carcinogen 3'-methyl-4-dimethylaminoazobenzene. Chem Biol Interact. 1970; 1(3):301-5. DOI: 10.1016/0009-2797(70)90016-5. View

SQUIRE R, Levitt M . Report of a workshop on classification of specific hepatocellular lesions in rats. Cancer Res. 1975; 35(11 Pt 1):3214-23. View

10.

FRIEDRICH-FREKSA H, GOSSNER W, Borner P . [Histochemical investigations of carcinogenesis in rat liver after continuous application of diethylnitrosamine]. Z Krebsforsch. 1969; 72(3):226-39. View

11.

RABES H, Hartenstein R, Scholze P . Specific stages of cellular response to homeostatic control during diethylnitrosamine-induced liver carcinogenesis. Experientia. 1970; 26(12):1356-9. DOI: 10.1007/BF02113030. View

12.

Rabes H, Scholze P, Jantsch B . Growth kinetics of diethylnitrosamine-induced, enzyme-deficient "preneoplastic" liver cell populations in vivo and in vitro. Cancer Res. 1972; 32(11):2577-86. View

13.

Van Cantfort J, Barbason H . Influence of a chronic administration of diethylnitrosamine on the relation between specific tissular and division functions in the rat liver. Eur J Cancer (1965). 1975; 11(8):531-6. DOI: 10.1016/0014-2964(75)90124-3. View

14.

WEISBURGER J, MADISON R, Ward J, Viguera C, WEISBURGER E . Modification of diethylnitrosamine liver carcinogenesis with phenobarbital but not with immunosuppression. J Natl Cancer Inst. 1975; 54(5):1185-8. DOI: 10.1093/jnci/54.5.1185. View

15.

Barbason H, BETZ E . [Study of the mitotic activity during the preneoplastic period in the liver of rats treated by diethylnitrosamine (author's transl)]. Experientia. 1976; 32(1):106-8. DOI: 10.1007/BF01932649. View

16.

Scherer E, Emmelot P . Foci of altered liver cells induced by a single dose of diethylnitrosamine and partial hepatectomy: their contribution to hepatocarcinogenesis in the rat. Eur J Cancer (1965). 1975; 11(3):145-54. DOI: 10.1016/0014-2964(75)90109-7. View

17.

PERAINO C, Fry R, STAFFELDT E, Christopher J . Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydantoin, and dichlorodiphenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat. Cancer Res. 1975; 35(10):2884-90. View

18.

Rajewsky M, Dauber W, Frankenberg H . Liver carcinogenesis by diethylnitrosamine in the rat. Science. 1966; 152(3718):83-5. DOI: 10.1126/science.152.3718.83. View