Alpha 2.0
Login Register
» Articles » PMID: 4758519

Cardiac Denervation in Diabetes

Overview
Journal Br Med J
Specialty General Medicine
Date 1973 Dec 8
PMID 4758519
Citations 132
Authors
T Wheeler
P J Watkins
Affiliations
Soon will be listed here.
Abstract

Evidence for vagal denervation of the heart as a feature of diabetic autonomic neuropathy has been obtained by monitoring beat-to-beat variation in heart rate. Nine diabetics with autonomic neuropathy were assessed; each showed a marked reduction or absence of beat-to-beat variation in comparison with controls. Beat-to-beat variation in normal subjects is abolished by parasympathetic blockade but unaffected by sympathetic blockade. These findings suggest that spontaneous vagal denervation of the heart was present in the cases studied. Measurement of beat-to-beat variation provides a simple test whereby cases of autonomic neuropathy can be screened for cardiac involvement.

Citing Articles

Examining the Light Heart Mobile Device App for Assessing Human Pulse Interval and Heart Rate Variability: Validation Study.

Klassen S, Jabbar J, Osborne J, Iannarelli N, Kirby E, OLeary D JMIR Form Res. 2024; 8:e56921.

PMID: 39163099 PMC: 11372322. DOI: 10.2196/56921.

Effects of continuous supplementation of Harms on the cardiac autonomic function of community-dwelling elderly individuals during resting and standing tests: a randomized controlled trial.

Sato T, Aoki T, Ito Y, Oishi K, Fujishima M, Okumura E Front Cardiovasc Med. 2024; 11:1336676.

PMID: 38525193 PMC: 10957529. DOI: 10.3389/fcvm.2024.1336676.

Simplified electrophysiological approach combining a point-of-care nerve conduction device and an electrocardiogram produces an accurate diagnosis of diabetic polyneuropathy.

Hayashi Y, Himeno T, Shibata Y, Hirai N, Asada-Yamada Y, Sasajima S J Diabetes Investig. 2024; 15(6):736-742.

PMID: 38421109 PMC: 11143421. DOI: 10.1111/jdi.14174.

Coefficient of R-R interval variations under deep breathing load in patients with wild-type transthyretin amyloid cardiomyopathy: A case-control study.

Nagayoshi Y, Kawano H, Nishihara T, Morikawa K, Nagano H, Hanatani S Health Sci Rep. 2022; 6(1):e938.

PMID: 36467751 PMC: 9710487. DOI: 10.1002/hsr2.938.

Power spectral analysis of heart rate variability is useful as a screening tool for detecting sympathetic and parasympathetic nervous dysfunctions in Parkinson's disease.

Miyagi T, Yamazato M, Nakamura T, Tokashiki T, Namihira Y, Kokuba K BMC Neurol. 2022; 22(1):339.

PMID: 36088296 PMC: 9463782. DOI: 10.1186/s12883-022-02872-2.

References
1.
Griepp R, Stinson E, DONG Jr E, Clark D, Shumway N . Hemodynamic performance of the transplanted human heart. Surgery. 1971; 70(1):88-96. View
2.
LEVY M, ZIESKE H . Autonomic control of cardiac pacemaker activity and atrioventricular transmission. J Appl Physiol. 1969; 27(4):465-70. DOI: 10.1152/jappl.1969.27.4.465. View
3.
Chamberlain D, Turner P, Sneddon J . Effects of atropine on heart-rate in healthy man. Lancet. 1967; 2(7505):12-5. DOI: 10.1016/s0140-6736(67)90057-8. View
4.
SHARPEY-SCHAFER E, Taylor P . Absent circulatory reflexes in diabetic neuritis. Lancet. 1960; 1(7124):559-62. DOI: 10.1016/s0140-6736(60)92773-2. View
5.
SAYERS B . The analysis of cardiac interbeat interval sequences and the effects of mental work load. Proc R Soc Med. 1971; 64(7):707-10. PMC: 1812108. View