Benzodiazepines and Tricyclic Antidepressant Plasma Levels

Overview

Journal Br Med J

Specialty General Medicine

Date 1973 Jul 7

PMID 4717418

Citations 12

Authors

G Silverman

R A Braithwaite

Affiliations

Soon will be listed here.

Abstract

Twelve patients acted successfully as subjects to study what effect if any the benzodiazepines nitrazepam, diazepam, oxazepam, and chlordiazepoxide might have on steady-state plasma levels of nortriptyline and amitriptyline. No significant detectable effect was discovered. In view of the known interaction effects of other alternative tranquillizing drugs and hypnotics it seems reasonable to choose benzodiazepines wherever possible when anxiolytics or hypnotics need to be added during treatment of depression with tricyclic antidepressants.

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The effects of hypnotics on imipramine treatment.

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References

Conney A . Pharmacological implications of microsomal enzyme induction. Pharmacol Rev. 1967; 19(3):317-66. View

GRUVSTAD M . Plasma levels on antidepressants and clinical response. Lancet. 1973; 1(7794):95-6. DOI: 10.1016/s0140-6736(73)90486-8. View

Conney A . Drug metabolism and therapeutics. N Engl J Med. 1969; 280(12):653-60. DOI: 10.1056/NEJM196903202801210. View

Prescott L . Drug metabolism and therapeutics. Scott Med J. 1971; 16(2):121-9. DOI: 10.1177/003693307101600201. View

Asberg M, CRONHOLM B, Sjoqvist F, Tuck D . Relationship between plasma level and therapeutic effect of nortriptyline. Br Med J. 1971; 3(5770):331-4. PMC: 1798656. DOI: 10.1136/bmj.3.5770.331. View

Breckenridge A, Orme M . Clinical implications of enzyme induction. Ann N Y Acad Sci. 1971; 179:421-31. DOI: 10.1111/j.1749-6632.1971.tb46919.x. View

Burrows G, Davies B . Antidepressants and barbiturates. Br Med J. 1971; 4(5779):113. PMC: 1799318. DOI: 10.1136/bmj.4.5779.113. View

Braithwaite R, Widdop B . A specific gas-chromatographic method for the measurement of "steady-state" plasma levels of amitriptyline and nortriptyline in patients. Clin Chim Acta. 1971; 35(2):461-72. DOI: 10.1016/0009-8981(71)90222-1. View

Braithwaite R, Goulding R, Theano G, Bailey J, Coppen A . Plasma concentration of amitriptyline and clinical response. Lancet. 1972; 1(7764):1297-300. DOI: 10.1016/s0140-6736(72)91031-8. View

10.

Orme M, Breckenridge A, Brooks R . Interactions of benzodiazepines with warfarin. Br Med J. 1972; 3(5827):611-4. PMC: 1785896. DOI: 10.1136/bmj.3.5827.611. View

11.

Mindham R, Howland C, Shepherd M . Continuation therapy with tricyclic antidepressants in depressive illness. Lancet. 1972; 2(7782):854-5. DOI: 10.1016/s0140-6736(72)92214-3. View

12.

Starr K, Petrie J . Drug interactions in patients on long-term oral anticoagulant and antihypertensive adrenergic neuron-blocking drugs. Br Med J. 1972; 4(5833):133-5. PMC: 1786384. DOI: 10.1136/bmj.4.5833.133. View

13.

Burrows G, Davies B, SCOGGINS B . Plasma concentration of nortriptyline and clinical response in depressive illness. Lancet. 1972; 2(7778):619-23. DOI: 10.1016/s0140-6736(72)93015-2. View

14.

Kragh-Sorensen P, Asberg M . Plasma-nortriptyline levels in endogenous depression. Lancet. 1973; 1(7795):113-5. DOI: 10.1016/s0140-6736(73)90192-x. View

15.

MOODY J, TAIT A, Todrick A . Plasma levels of imipramine and desmethylimipramine during therapy. Br J Psychiatry. 1967; 113(495):183-93. DOI: 10.1192/bjp.113.495.183. View