Faecal Bile-acids and Clostridia in Patients with Cancer of the Large Bowel

Overview

Journal Lancet

Publisher Elsevier

Specialty General Medicine

Date 1975 Mar 8

PMID 47015

Citations 75

Authors

M J Hill

B S Drasar

R E Williams

T W Meade

A G Cox

J E Simpson

B C MORSON

Affiliations

Soon will be listed here.

Abstract

Of 44 patients with cancer of the large bowel, 36 ( 82%) had high faecal bile-acid concentrations compared with only 15 (17%) out of 90 patients with other diseases. 31 (70%) of the 44 patients with large-bowel cancer had high faecal bile-acid concentrations in the presence of faecal clostridia able to dehydrogenate the bile-acid nucleus, compared with only 8 (9%) out of 90 patients with other diseases. Thes findings support the hypothesis that cancer of the large bowel is caused by high concentrations of bile-acid derivatives produced by certain anaerobic bacteria.

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