Lymphocyte Transformation in the Mesenteric Lymph Nodes of Patients with Crohn's Disease

Overview

Journal Gut

Specialty Gastroenterology

Date 1973 Jan 1

PMID 4692250

Citations 12

Authors

P J Guillou

T G Brennan

G R Giles

Affiliations

Soon will be listed here.

Abstract

The response of lymphocytes from peripheral blood and mesenteric lymph nodes to stimulation with phytohaemagglutinin in vitro has been studied in eight patients suffering from active Crohn's disease. Patients with Crohn's disease exhibited reduced responses when compared with similar studies performed in control subjects. The impaired responses of circulating lymphocytes from these patients were marked on culture in autologous serum and were not improved by culture in homologous AB serum. Lymphocytes from lymph nodes directly draining diseased bowel exhibited lower responses than those from nodes at the root of the mesentery, which in turn were lower than those of circulating lymphocytes.

Citing Articles

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Peripheral blood and mesenteric lymph node lymphocytes in Crohn's disease.

Richens E, Thorp C, Bland P, GOUGH K Gut. 1980; 21(6):507-11.

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The immune competence of patients with inflammatory bowel disease.

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Leucocyte migration studies in Crohn's disease using Crohn's colon homogenate and mitochondrial and microsomal fractions.

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