Urinary Catecholamine Metabolites During Behavioral Changes in a Patient with Manic-depressive Cycles

Overview

Journal Science

Specialty Science

Date 1973 Jan 19

PMID 4683130

Citations 9

Authors

F D JONES

J W Maas

H Dekirmenjian

J A Fawcett

Affiliations

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Abstract

3-Methoxy-4-hydroxyphenylglycol and normetanephrine were analyzed in daily urine specimens of a patient with manic-depressive cycles who was studied longitudinally. The quantities of these catecholamine metabolites excreted into urine were decreased during periods of depression as compared with periods of mania. Urinary excretion of 3-methoxy-4-hydroxyphenylglycol varied cyclically with a period length of approximately 20 days. Changes in this metabolite, and perhaps in normetanephrine, preceded the affective and behavioral shifts.

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