Physicochemical Properties of Neisseria Meningitidis Group X Polysaccharide Antigen

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1972 Nov 1

PMID 4629206

Citations 2

Authors

M A Apicella

J A Robinson

Affiliations

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Abstract

Neisseria meningitidis group X occurs in human carrier populations and is rarely implicated in serious disease. This organism possesses a capsular group antigen which is an acidic polysaccharide. It is composed of the amino sugars, glucosamine, glucosamine-6-phosphate, galactosamine, and the simple hexose, glucose. The group X capsular antigen has an S(20,w) (0) of 3.6, and the acidic nature of the polysaccharide is reflected in an isoelectric point of 3.65. The meningococcal A, B, C, and Y polysaccharide group antigens are also composed primarily of amino sugars. The chemical composition of the group X antigen most closely resembles the capsular antigen of N. meningitidis group Y, which is also predominately a carrier organism.

Citing Articles

The meningococcus and mechanisms of pathogenicity.

DeVoe I Microbiol Rev. 1982; 46(2):162-90.

PMID: 6126800 PMC: 281537. DOI: 10.1128/mr.46.2.162-190.1982.

Immunological and biochemical studies of meningococcal C polysaccharides isolated by diethylaminoethyl chromatography.

Apicella M Infect Immun. 1976; 14(1):106-13.

PMID: 181322 PMC: 420851. DOI: 10.1128/iai.14.1.106-113.1976.

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