Effect of Heparin on Renal Function in Patients with Oliguria

Overview

Journal Br Med J

Specialty General Medicine

Date 1972 Oct 21

PMID 4627879

Citations 2

Authors

E N Wardle

P R ULDALL

Affiliations

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Abstract

The effect of short-term administration of heparin has been studied in seven patients with oliguric glomerulonephritis, five with accelerated hypertension, and three with transplant rejection. Measurements were made of the glomerular filtration rate, radiofibrinogen catabolism, and complement inhibition. Beneficial effects on fibrinogen catabolism were found in some cases of accelerated hypertension and transplant rejection, but heparin alone had no dramatic effect in glomerulonephritis. Heparin produced an increase of glomerular filtration rate, but in-vivo inhibition of complement by heparin was small.

Citing Articles

The effects of heparin treatment on hypertension and vascular lesions in stroke-prone spontaneously hypertensive rats.

Wilson S, Solez K, Boitnott J, HEPTINSTALL R Am J Pathol. 1981; 102(1):62-71.

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Fibrinogen catabolism study of three patients with bacterial endocarditis and renal disease.

Wardle E, Floyd M Br Med J. 1973; 3(5874):255-7.

PMID: 4269230 PMC: 1586716. DOI: 10.1136/bmj.3.5874.255.

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