Carrier-determined Tolerance in Vitro

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 1975 Jan 1

PMID 46237

Citations 4

Authors

P Galanaud

Y Borel

Affiliations

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Abstract

A primary immune response to normal BDF1 spleen cells was obtained in vitro to the T-independent antigen TNP-T4 coliphage. This anti-TNP response was suppressed by exposing the spleen cells for 6 hr to TNP bound either to isologous or heterologous gamma-globulin. The suppression was hapten specific. In contrast, TNP-albumin conjugates did not induce tolerance in vitro.

Citing Articles

Induction of tolerance by administration of hapten-immunoglobulin conjugates is associated with decreased IL-2 and IL-4 production.

Dumas V, Ptak W, Demarchez M, Saurat J, Borel Y, Hauser C Arch Dermatol Res. 1995; 287(2):123-8.

PMID: 7763082 DOI: 10.1007/BF01262319.

Effect of azathioprine on in vitro antibody response. Differential effect on B cells involved in thymus-dependent and independent responses.

Galanaud P, Crevon M, Dormont J Clin Exp Immunol. 1975; 22(1):139-52.

PMID: 1082392 PMC: 1538326.

Can B-cell tolerance be induced by oligovalent thymus dependent antigens?.

Waldmann H, Pope H Immunology. 1977; 32(5):657-67.

PMID: 301114 PMC: 1445321.

Induction if immunological tolerance to the major antigenic determinant of penicillin: a therapeutic approach to penicillin allergy.

Chiorazzi N, Eshhar Z, Katz D Proc Natl Acad Sci U S A. 1976; 73(6):2091-5.

PMID: 59360 PMC: 430455. DOI: 10.1073/pnas.73.6.2091.