Drug Discrimination Training with Progressively Lowered Doses

Overview

Journal Science

Specialty Science

Date 1979 Aug 17

PMID 462182

Citations 18

Authors

D A OVERTON

Affiliations

Soon will be listed here.

Abstract

Rats were trained to discriminate drug from no-drug conditions in a two-lever operant task. Moderately high dosages were used initially. Whenever the discrimination was learned, training was continued with progressively reduced dosages. Eventually the rats discriminated extremely low doses of phenobarbital, chlordiazepoxide, cyclazocine, and fentanyl.

Citing Articles

The route to recall a dream: theoretical considerations and methodological implications.

Nemeth G Psychol Res. 2022; 87(4):964-987.

PMID: 35960337 DOI: 10.1007/s00426-022-01722-7.

Measurement of the lowest dosage of phenobarbital that can produce drug discrimination in rats.

Overton D, Stanwood G, Patel B, Pragada S, Gordon M Psychopharmacology (Berl). 2008; 203(2):213-8.

PMID: 19082992 PMC: 2782425. DOI: 10.1007/s00213-008-1426-y.

Early preclinical studies of discriminable sedative and hallucinogenic drug effects.

Barry 3rd H, Appel J Psychopharmacology (Berl). 2008; 203(2):193-201.

PMID: 18712362 DOI: 10.1007/s00213-008-1292-7.

Discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats.

Jarbe T, Li C, Vadivel S, Makriyannis A Psychopharmacology (Berl). 2008; 198(4):467-78.

PMID: 18264696 PMC: 3678952. DOI: 10.1007/s00213-008-1076-0.

Drug discrimination by humans compared to nonhumans: current status and future directions.

Kamien J, Bickel W, Hughes J, Higgins S, Smith B Psychopharmacology (Berl). 1993; 111(3):259-70.

PMID: 7870962 DOI: 10.1007/BF02244940.