Embryonic Antigen Expression on 2-acetylaminofluorene Induced and Spontaneously Arising Rat Tumours

Overview

Journal Br J Cancer

Specialty Oncology

Date 1974 Sep 1

PMID 4615731

Authors

R W Baldwin

B M Vose

Affiliations

Soon will be listed here.

Abstract

2-Acetylaminofluorene induced mammary and ear duct carcinomata and spontaneously arising mammary carcinomata and sarcomata were shown to express embryonic antigens at the cell surface by their reaction with serum from multiparous female rats. These observations with essentially non-immunogenic tumours are comparable with early findings showing that embryonic antigens are also expressed on aminoazo dye induced rat hepatomata, and sarcomata induced with 3-methylcholanthrene. Re-expression of embryonal components, therefore, may be a concomitant of neoplastic transformation.

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