Protection Against Gram-negative Infections with Antiserum to Lipid A from Salmonella Minnesota R595

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1974 Dec 1

PMID 4611919

Citations 24

Authors

N A Mullan

P M Newsome

P G Cunnington

G H Palmer

M E Wilson

Affiliations

Soon will be listed here.

Abstract

The ability of antisera to lipid A, induced in rabbits by immunization with lipid A complexed to various carriers, to protect mice against gram-negative infection and to inhibit the fluid loss caused by an enteropathogenic strain of Escherichia coli in the piglet ligated gut was investigated. No significant protection was obtained in either case, although passive hemolysis and quantitative precipitation tests showed the presence of antilipid A antibodies in the sera. Fluorescent antibody studies suggest that the lipid A is in a cryptic position on the surface of smooth strains of gram-negative bacteria.

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