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Uptake of Immune RNA by Normal Mouse Spleen Cells

Overview
Publisher Springer
Specialty Biochemistry
Date 1979 Mar 5
PMID 460172
Citations 1
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Abstract

Normal mouse spleen cells take up in vitro radioactively labeled immune RNA. RNA taken up is present in nuclei, polysomes, membranes and cytoplasm. About 20-40% of immune RNA is nonspecifically associated with cell surface. 45% of RNA taken up is degraded and reutilized inside the cells within 2 hours.

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References
1.
Britten R, Davidson E . Gene regulation for higher cells: a theory. Science. 1969; 165(3891):349-57. DOI: 10.1126/science.165.3891.349. View

2.
Bell C, Dray S . Conversion of non-immune spleen cells by ribonucleic acid of lymphoid cells from an immunized rabbit to produce gammaM antibody of foreign light chain allotype. J Immunol. 1969; 103(6):1196-211. View

3.
Kern D, PILCH Y . Antitumor antibody synthesis in vitro induced in mouse spleen cells by xenogeneic immune RNA. J Natl Cancer Inst. 1978; 60(3):599-603. DOI: 10.1093/jnci/60.3.599. View

4.
Fishman M, ADLER F, Rice S . RNA in the vitro immune response. Macrophage RNA in the in vitro immune response to phage. Ann N Y Acad Sci. 1973; 207:73-82. DOI: 10.1111/j.1749-6632.1973.tb47477.x. View

5.
Loening U . The determination of the molecular weight of ribonucleic acid by polyacrylamide-gel electrophresis. The effects of changes in conformation. Biochem J. 1969; 113(1):131-8. PMC: 1184612. DOI: 10.1042/bj1130131. View