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Induction of Haemophilus Influenzae Type B Capsular Antibody in Neonatal Rabbits by Gastrointestinal Colonization with Cross-reacting Escherichia Coli

Overview
Journal Infect Immun
Publisher American Society for Microbiology
Specialty Allergy & Immunology
Date 1973 Feb 1
PMID 4572607
Citations 7
Authors
R L Myerowitz
Z T Handzel
R Scheerson
J B Robbins
Affiliations
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Abstract

In two separate experiments, newborn rabbits were fed a live suspension of either of two Escherichia coli strains which possess a "K" antigen cross-reactive with the capsular polysaccharide of Haemophilus influenzae type b. Both feedings were harmless and resulted in fecal excretion of the fed E. coli in most animals as well as active immunization of fed animals toward H. influenzae type b. Feeding non-enteropathogenic, cross-reacting E coli to newborns may be a method for inducing active immunity toward H. influenzae type b diseases by accelerating the acquisition of "natural" immunity.

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Editorial: Haemophilus influenzae infections.

Br Med J. 1974; 2(5917):462.

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Heteroimmunization to the capsular polysaccharide of Haemophilus influenzae type b induced by enteric cross-reacting bacteria.

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Effect of neonatal gastrointestinal colonization with cross reacting Escherichia coli on anticapsular antibody production and bacteremia in experimental Haemophilus influenzae type b disease of rats.

Myerowitz R, NORDEN C Infect Immun. 1977; 17(1):83-90.

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References
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