Morphologic Study of the Participation of the Complement System in Hyperacute Rejection of Renal Xenotransplants

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1972 Oct 1

PMID 4562798

Citations 3

Authors

A Martinez-Palomo

C E BIRO

B Chavez

F Lopez-Soriano

Affiliations

Soon will be listed here.

Abstract

The role of polymorphonuclear leukocyte (PMN) and platelet infiltration in the hyperacute rejection of renal xenotransplants was studied. In a first group, a dog kidney was grafted to rabbit recipients with intact immune adherence and chemotaxis. A second group included recipients depleted of PMN's with nitrogen mustard, and in a third group, immune adherence and chemotaxis were modified by depleting the third component of complement by means of cobra venom factor. Serial kidney biopsies were studied with light and electron microscopic technics. A semiquantitative evaluation of PMN and platelet glomerular infiltration indicated that a reduction in the number of PMN's or platelets is associated with an increased survival time of the transplanted kidney.

Citing Articles

Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients.

Dalmasso A, Vercellotti G, Fischel R, Bolman R, Bach F, Platt J Am J Pathol. 1992; 140(5):1157-66.

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Immunofluorescent localization of pig complement component 3, regardless of the presence or absence of detectable immunoglobulins, in hyperacutely rejected heart xenografts.

Wang M, Johnston P, Wright L, Lim S, White D Histochem J. 1992; 24(2):102-9.

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The production of lesions in the rabbit kidney by xenoperfusion with fresh human blood.

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