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Specificity of Interaction Between the First Enzyme for Histidine Biosynthesis and Aminoacylated Histidine Transfer Ribonucleic Acid

Overview
Journal J Bacteriol
Publisher American Society for Microbiology
Specialty Microbiology
Date 1972 Oct 1
PMID 4562388
Citations 11
Authors
T Vogel
M Meyers
J S Kovach
R F GOLDBERGER
Affiliations
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Abstract

The specificity of the interaction between phosphoribosyltransferase and partially purified preparations of various species of transfer ribonucleic acid (tRNA) was investigated with the use of a filter binding assay. The enzyme showed a higher affinity for histidyl-tRNA than for arginyl- or glutamyl-tRNA. Competition experiments revealed that the enzyme does not distinguish between the aminoacylated and deacylated forms of arginine tRNA or glutamic acid tRNA, since all the binding of the aminoacylated tRNA could be inhibited by deacylated tRNA. The enzyme does, however, distinguish between the aminoacylated and deacylated forms of histidine tRNA. Approximately 70% of the binding of aminoacylated histidine tRNA is specific, since only 30% of the binding could be inhibited by deacylated tRNA. The possibility that the regulatory role of phosphoribosyltransferase is carried out as a complex with histidyl-tRNA is consistent with these data.

Citing Articles

Defective in vitro binding of histidyl-transfer ribonucleic acid to feedback resistant phosphoribosyl transferase of Salmonella typhimurium.

Smith O, MEYERS M, Vogel T, Deeley R, Goldberger R Nucleic Acids Res. 1974; 1(7):881-8.

PMID: 10793720 PMC: 343391. DOI: 10.1093/nar/1.7.881.

Autogenous regulation of gene expression.

Maloy S, Stewart V J Bacteriol. 1993; 175(2):307-16.

PMID: 8419283 PMC: 196143. DOI: 10.1128/jb.175.2.307-316.1993.

In vitro transcription of the Escherichia coli histidine operon.

Avitabile A, Bruni C, Covelli A, Di Nocera P, Sbordone L, Blasi F Mol Gen Genet. 1974; 132(1):1-12.

PMID: 4608432 DOI: 10.1007/BF00268225.

Role for free isoleucine of glycyl-leucine in the repression of threonine deaminase in Escherichia coli.

Wasmuth J, Umbarger H J Bacteriol. 1974; 117(1):29-39.

PMID: 4587610 PMC: 246521. DOI: 10.1128/jb.117.1.29-39.1974.

Inhibition of transcription of the histidine operon in vitro by the first enzyme of the histidine pathway.

Blasi F, Bruni C, Avitabile A, Deeley R, GOLDBERGER R, MEYERS M Proc Natl Acad Sci U S A. 1973; 70(9):2692-6.

PMID: 4582195 PMC: 427085. DOI: 10.1073/pnas.70.9.2692.

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