Clinical Screening of Epipodophyllotoxin VM26 in Malignant Lymphomas and Solid Tumours

Overview

Journal Br Med J

Specialty General Medicine

Date 1972 Jun 24

PMID 4556544

Citations 9

Affiliations

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Abstract

Epipodophyllotoxin (VM 26; 4'-demethyl-epipodophyllotoxin-beta-D-thenylidene glucoside) has been proved, in clinical screening, to be able to induce apparently complete remissions and pronounced though incomplete regressions in Hodgkin's disease, reticulosarcoma, and bladder cancer, as well as incomplete regressions in lymphosarcoma. Apparently complete regressions of malignant pleural effusions have been obtained after giving this drug systemically. It has a notable toxic action on the bone marrow.

Citing Articles

Teniposide: overview of its therapeutic potential in adult cancers.

Muggia F Cancer Chemother Pharmacol. 1994; 34 Suppl:S127-33.

PMID: 8070021 DOI: 10.1007/BF00684876.

VM26: phase I and II studies.

Macbeth F Cancer Chemother Pharmacol. 1982; 7(2-3):87-91.

PMID: 7044595 DOI: 10.1007/BF00254527.

The podophyllotoxin derivatives VP16-213 and VM26.

Issell B Cancer Chemother Pharmacol. 1982; 7(2-3):73-80.

PMID: 7044593 DOI: 10.1007/BF00254525.

[Diagnostic and therapeutic procedures in Hodgkin's disease].

Huhn D, Steidle C Blut. 1973; 27(2):105-30.

PMID: 4586834 DOI: 10.1007/BF01632001.

Phase II evaluation of teniposide (VM-26) in metastatic breast carcinoma. A Southeastern Cancer Study Group trial.

Cox E, Vogel C, CARPENTER Jr J, Raney M Invest New Drugs. 1988; 6(1):37-9.

PMID: 3410666 DOI: 10.1007/BF00170777.

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