Vindesine As a Single Agent in the Treatment of Advanced Malignant Melanoma

Overview

Journal Cancer Chemother Pharmacol

Specialty Oncology

Date 1979 Jan 1

PMID 455584

Citations 6

Authors

S Retsas

K A Newton

G Westbury

Affiliations

Soon will be listed here.

Abstract

The antitumour effect of vindesine (desacetyl vinvlastine amide sulfate) in disseminated malignant melanoma has been investigated in our oncology service in a phase-II study. Of 25 patients exposed to the drug, 23 were evaluable, and seven of these (30%) were considered objective responders. The observed response of malignant effusions is of particular interest. Side effects related to vindesine are similar to those of the other vinca alkaloids, although alopecia may be more pronounced with the doses used in this study.

Citing Articles

[Therapy of malignant melanoma at the stage of distant metastasis].

Garbe C, Eigentler T Hautarzt. 2004; 55(2):195-213.

PMID: 15043023 DOI: 10.1007/s00105-003-0684-1.

[Combination chemotherapy with cis-dichloro-diammineplatinum (II) and ifosfamide in malignant melanomas (author's transl)].

Balda B, Jehn U, Klovekorn W, Wohlrab A Klin Wochenschr. 1981; 59(14):781-6.

PMID: 7196477 DOI: 10.1007/BF01724683.

Establishment of Vincristine-resistant and vindesine-resistant lines of murine lymphoblasts in vitro and characterisation of their patterns of cross-resistance and drug sensitivities.

Hill B, Whelan R Cancer Chemother Pharmacol. 1982; 8(2):163-9.

PMID: 7105380 DOI: 10.1007/BF00255477.

Vindesine in advanced breast cancer, lymphoma and melanoma. A Colorado Clinical Oncology Group study.

DiBella N, BERRIS R, Garfield D, Fink K, Speer J, Sakamoto A Invest New Drugs. 1984; 2(3):323-8.

PMID: 6511238 DOI: 10.1007/BF00175385.

Dacarbazine versus dacarbazine-vindesine in disseminated malignant melanoma: a randomized phase II study.

Ringborg U, RUDENSTAM C, Hansson J, Hafstrom L, Stenstam B, Strander H Med Oncol Tumor Pharmacother. 1989; 6(4):285-9.

PMID: 2693850 DOI: 10.1007/BF02985163.

References

DYKE R, Nelson R . Phase I anti-cancer agents: vindesine (desacetyl vinblastine amide sulfate). Cancer Treat Rev. 1977; 4(2):135-42. DOI: 10.1016/s0305-7372(77)80010-8. View

Comis R, Carter S . Integration of chemotherapy into combined modality therapy of solid tumors. IV. Malignant melanoma. Cancer Treat Rev. 1974; 1(4):285-304. DOI: 10.1016/s0305-7372(74)80020-4. View

MCKELVEY E, LUCE J, TALLEY R, Hersh E, HEWLETT J, MOON T . Combination chemotherapy with bis chloroethyl nitrosourea (BCNU), vincristine and dimethyl triazeno imidazole carboxamide (DTIC) in disseminated malignant melanoma. Cancer. 1977; 39(1):1-4. DOI: 10.1002/1097-0142(197701)39:1<1::aid-cncr2820390102>3.0.co;2-r. View

Costanza M, NATHANSON L, Schoenfeld D, Wolter J, COLSKY J, Regelson W . Results with methyl-CCNU and DTIC in metastatic melanoma. Cancer. 1977; 40(3):1010-5. DOI: 10.1002/1097-0142(197709)40:3<1010::aid-cncr2820400308>3.0.co;2-c. View

Einhorn L, Furnas B . Combination chemotherapy for disseminated malignant melanoma with DTIC, vincristine, and methyl-CCNU. Cancer Treat Rep. 1977; 61(5):881-3. View