Stimulation of Unbalanced Ribonucleic Acid Synthesis in Escherichia Coli by Methanol

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1972 Apr 1

PMID 4552987

Citations 4

Authors

G T Javor

Affiliations

Soon will be listed here.

Abstract

Addition of methanol to a stringent strain of Escherichia coli, starving of methionine, stimulates unbalanced ribonucleic acid (RNA) synthesis. The newly formed RNA and ribonucleoprotein species sediment between 4S and 30S. As a result of methanol treatment, cells become permeable to actinomycin D. Damage to cellular membrane appears to influence the control for RNA synthesis.

Citing Articles

Inhibition of Escherichia coli by thioglycerol.

Jensen K, Javor G Antimicrob Agents Chemother. 1981; 19(4):556-61.

PMID: 6166247 PMC: 181476. DOI: 10.1128/AAC.19.4.556.

Inhibition of ribonucleic acid synthesis by nalidixic acid in Escherichia coli.

Javor G J Bacteriol. 1974; 120(1):282-6.

PMID: 4607671 PMC: 245761. DOI: 10.1128/jb.120.1.282-286.1974.

Stability of Escherichia coli membrane proteins during chloramphenicol treatment.

Bacchus A, Javor G Antimicrob Agents Chemother. 1975; 8(3):387-9.

PMID: 1101826 PMC: 429327. DOI: 10.1128/AAC.8.3.387.

Effect of dichlorodifluoromethane on the appearance, viability, and integrity of Escherichia coli.

Prior B, Fennema O, Pate J Appl Microbiol. 1975; 29(5):685-91.

PMID: 1096819 PMC: 187057. DOI: 10.1128/am.29.5.685-691.1975.

References

CASHEL M, Gallant J . Two compounds implicated in the function of the RC gene of Escherichia coli. Nature. 1969; 221(5183):838-41. DOI: 10.1038/221838a0. View

Davis B, MINGIOLI E . Mutants of Escherichia coli requiring methionine or vitamin B12. J Bacteriol. 1950; 60(1):17-28. PMC: 385836. DOI: 10.1128/jb.60.1.17-28.1950. View

TROPP B, Meade L, Thomas P . Consequences of expression of the "relaxed" genotype of the RC gene. Lipid synthesis. J Biol Chem. 1970; 245(4):855-8. View

Dalgarno L, Gros F . RNA synthesis in "relaxed" and "stringent" Escherichia coli. Breakdown of performed ribonucleoprotein particles and subsequent RNA synthesis. Biochim Biophys Acta. 1968; 157(1):64-75. View

Edlin G, Stent G . Nucleoside triphosphate pools and the regulation of RNA synthesis in E. coli. Proc Natl Acad Sci U S A. 1969; 62(2):475-82. PMC: 277823. DOI: 10.1073/pnas.62.2.475. View

Wong J, Nazar R . Relationship of the MS nucleotides to the regulation of ribonucleic acid synthesis in Escherichia coli. J Biol Chem. 1970; 245(17):4591-3. View

CASHEL M, Kalbacher B . The control of ribonucleic acid synthesis in Escherichia coli. V. Characterization of a nucleotide associated with the stringent response. J Biol Chem. 1970; 245(9):2309-18. View

Gallant J, CASHEL M . On the mechanism of amino acid control of ribonucleic acid biosynthesis. J Mol Biol. 1967; 25(3):545-53. DOI: 10.1016/0022-2836(67)90205-7. View

Pardee A, PRESTIDGE L . The dependence of nucleic acid synthesis on the presence of amino acids in Escherichia coli. J Bacteriol. 1956; 71(6):677-83. PMC: 314583. DOI: 10.1128/jb.71.6.677-683.1956. View

10.

Stent G, Brenner S . A genetic locus for the regulation of ribonucleic acid synthesis. Proc Natl Acad Sci U S A. 1961; 47:2005-14. PMC: 223254. DOI: 10.1073/pnas.47.12.2005. View

11.

Aronson A, Spiegelman S . Protein and ribonucleic acid synthesis in a chloramphenicol-inhibited system. Biochim Biophys Acta. 1961; 53:70-84. DOI: 10.1016/0006-3002(61)90795-8. View

12.

Nakada D, Marquisee M . Relaxed synthesis of ribosomal RNA by a stringent strain of Escherichia coli. J Mol Biol. 1965; 13(2):351-61. DOI: 10.1016/s0022-2836(65)80102-4. View

13.

BOREK E, Ryan A, ROCKENBACH J . Nucleic acid metabolism in relation to the lysogenic phenomenon. J Bacteriol. 1955; 69(4):460-7. PMC: 357560. DOI: 10.1128/jb.69.4.460-467.1955. View

14.

EZEKIEL D, Elkins B . The stimulation of ribonucleic acid synthesis by ribosome inhibitors in amino acid-starved Escherichia coli. Biochim Biophys Acta. 1968; 166(2):466-74. DOI: 10.1016/0005-2787(68)90234-7. View

15.

CASHEL M, Gallant J . Control of RNA synthesis in Escherichia coli. I. Amino acid dependence of the synthesis of the substrates of RNA polymerase. J Mol Biol. 1968; 34(2):317-30. DOI: 10.1016/0022-2836(68)90256-8. View

16.

Raina A, Jansen M, COHEN S . Polyamines and the accumulation of ribonucleic acid in some polyauxotrophic strains of Escherichia coli. J Bacteriol. 1967; 94(5):1684-96. PMC: 276879. DOI: 10.1128/jb.94.5.1684-1696.1967. View

17.

Raina A, COHEN S . Polyamines and RNA synthesis in a polyauxotrophic strain of E. coli. Proc Natl Acad Sci U S A. 1966; 55(6):1587-93. PMC: 224363. DOI: 10.1073/pnas.55.6.1587. View

18.

TREMBLAY G, Daniels M, Schaechter M . Isolation of a cell membrane-DNA-nascent RNA complex from bacteria. J Mol Biol. 1969; 40(1):65-76. DOI: 10.1016/0022-2836(69)90296-4. View

19.

Irr J, Gallant J . The control of ribonucleic acid synthesis in Escherichia coli. II. Stringent control of energy metabolism. J Biol Chem. 1969; 244(8):2233-9. View

20.

Gallant J, Harada B . The control of ribonucleic acid synthesis in Escherichia coli. 3. The functional relationship between purine ribonucleoside triphosphate pool sizes and the rate of ribonucleic acid accumulation. J Biol Chem. 1969; 244(12):3125-32. View