Self-association of Cholesterol in Aqueous Solution

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1973 Aug 1

PMID 4525165

Citations 50

Authors

M E Haberland

J A Reynolds

Affiliations

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Abstract

Cholesterol has a maximum solubility in aqueous solutions of 1.8 mug/ml or 4.7 muM. It undergoes a thermodynamically reversible self-association with a critical micelle concentration of 25 to 40 nM at 25 degrees . The cholesterol micelle is heterogeneous in size, probably rodlike in shape, and stabilized by an unusually high interaction energy between the aggregated monomers.

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