Mechanism of Lysergic Acid Diethylamide Interference with Rabbit Antibody Biosynthesis

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1974 Apr 1

PMID 4524614

Citations 2

Authors

E W Voss Jr

J L Winkelhake

Affiliations

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Abstract

Lymphoid cells from hyperimmune rabbits producing antibodies to a hapten, incubated in the presence of d-lysergic acid diethylamide, continued to synthesize protein at a normal rate. Isoelectric focusing analysis of the low-molecular-weight protein secreted by the cells incubated with lysergic acid diethylamide indicated two components, with pI's of 4.9 and 5.2. Immune cells not exposed to lysergic acid diethylamide secreted only 7S IgG molecules with an average pI of approximately 7.0.

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