Environmental Stimuli in the Progression of BHK-21 Cells Through the Cell Cycle

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1972 Jun 1

PMID 4504358

Citations 10

Authors

M Shodell

Affiliations

Soon will be listed here.

Abstract

An L-cell line adapted to grow in protein-free medium is a source of material that stimulates the proliferation of serum-dependent BHK cells under otherwise protein-free conditions. The material produced by the L-cells is resolvable into separate DNA-synthetic and mitotic stimulatory activities. The stimulation of mitosis is dependent upon the presence of one or more heat-labile macromolecules, which can be concentrated by ultrafiltration, and at least one dialyzable component is essential for the initiation of DNA synthesis.

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