Macromolecular Synthesis in Mitochondria Isolated from Different Regions of Developing Rat Brain

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 1979 Feb 1

PMID 450171

Citations 10

Authors

M N Gadaleta

A M GIUFFRIDA

M Renis

I Serra

G Del Prete

E Geremia

C Saccone

Affiliations

Soon will be listed here.

Abstract

DNA, RNA, and protein synthesis in mitochondria isolated from cerebral hemispheres, brain stem, and cerebellum of 10- and 30-day-old rats was measured. Synthesis of different macromolecules was affected by the respective mitochondrial specific inhibitors, showing a good level of purity of mitochondrial preparations. DNA and protein synthesis in 10-day-old rats was about 70% higher than in 30-day-old animals. In contrast, RNA synthesis did not decrease with age in all the regions examined.

Citing Articles

DNA polymerase and thymidine kinase activities in different regions of rat brain during postnatal development: effect of undernutrition.

Serra I, Vanella A, Avola R, GIUFFRIDA A Neurochem Res. 1982; 7(8):943-51.

PMID: 7144998 DOI: 10.1007/BF00965134.

RNA synthesis in neuronal and glial cell nuclei from rat cerebral hemispheres during early postnatal development.

Serra I, Avola R, Vanella A, Lombardo B, Agodi A, GIUFFRIDA A Neurochem Res. 1984; 9(8):1051-63.

PMID: 6208492 DOI: 10.1007/BF00964801.

Labeling of RNA in young and adult rat brain: evidence for different RNA processing.

Serra I, Cupello A, Gadaleta M, Viola M, Ragonese P, GIUFFRIDA A Neurochem Res. 1983; 8(4):433-47.

PMID: 6193440 DOI: 10.1007/BF00965100.

Effect of undernutrition on DNA and RNA synthesis in subcellular fractions from different regions of the developing rat brain.

Serra I, Hamberger A, Ragonese P, GIUFFRIDA A Neurochem Res. 1982; 7(8):887-904.

PMID: 6183599 DOI: 10.1007/BF00965130.

Effect of CDP-choline on the biosynthesis of nucleic acids and proteins in brain regions during hypoxia.

Serra I, Alberghina M, Viola M, Mistretta A, GIUFFRIDA A Neurochem Res. 1981; 6(6):607-18.

PMID: 6168928 DOI: 10.1007/BF00963878.

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