Immunoreactive Carcinoembryonic Antigen [CEA] Levels in Feces from Colorectal Cancer Patients

Overview

Journal Jpn J Surg

Specialty General Surgery

Date 1979 Jun 1

PMID 449127

Citations 3

Authors

Y Kitsukawa

Affiliations

Soon will be listed here.

Abstract

Immunoreactive CEA (IR-CEA) in feces or sera from 20 volunteers and 20 patients with colorectal cancer were measured before and at various intervals after surgery by a radioimmunoassay utilizing a "one step sandwich method." Elevated fecal IR-CEA level was observed in 17 of 20 patients with colorectal cancer; elevated serum CEA levels were observed in only 7 of all patients. There could not be found any correlation between fecal IR-CEA levels and Dukes' classification; there was but a little correlation between serum and fecal IR-CEA levels. In 8 of 14 patients treated by surgery, fecal IR-CEA levels obviously dropped, but in 2 patients with hepatic metastasis they were found rising in spite of colon tumor removal. It was speculated from these data that high values of fecal CEA depend on mass production of CEA by cancer cells. From these observations, it appears that fecal IR-CEA level presents a more ideal diagnostic competency in colorectal cancer than serum CEA level.

Citing Articles

Potential of Fecal Carcinoembryonic Antigen for Noninvasive Detection of Colorectal Cancer: A Systematic Review.

Li X, Stassen L, Schrotz-King P, Zhao Z, Cardoso R, Raut J Cancers (Basel). 2023; 15(23).

PMID: 38067360 PMC: 10705067. DOI: 10.3390/cancers15235656.

Fecal CEA Has an Advantage in the Diagnosis of Colorectal Cancer at Early Stage.

Li L, Xing S, Wu M, Ao Y, Zheng X, Cai R Cancer Control. 2021; 28:10732748211048292.

PMID: 34615391 PMC: 8504688. DOI: 10.1177/10732748211048292.

Further investigations of immunoreactive carcinoembryonic antigen (CEA) in colorectal cancer patients--with particular emphasis on the correlation between immunoreactive CEA levels in tissue, feces and blood.

Fujimoto S, Kitsukawa Y Jpn J Surg. 1981; 11(1):27-32.

PMID: 7311185 DOI: 10.1007/BF02468816.

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