Pharmacokinetics of the Warfarin Enantiomers in Rats

Overview

Journal J Pharmacokinet Biopharm

Specialty Pharmacology

Date 1974 Jun 1

PMID 4452939

Citations 9

Authors

A Yacobi

G Levy

Affiliations

Soon will be listed here.

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References

Breimer D, van Rossum J . Letter: Pharmacokinetics of (+)-, (-)- and (plus or minus)-hexobarbitone in man after oral administration. J Pharm Pharmacol. 1973; 25(9):762-4. DOI: 10.1111/j.2042-7158.1973.tb10066.x. View

Hewick D, McEwen J . Plasma half-lives, plasma metabolites and anticoagulant efficacies of the enantiomers of warfarin in man. J Pharm Pharmacol. 1973; 25(6):458-65. DOI: 10.1111/j.2042-7158.1973.tb09133.x. View

OReilly R . Interaction of several coumarin compounds with human and canine plasma albumin. Mol Pharmacol. 1971; 7(2):209-18. View

Yacobi A, Wingard Jr L, Levy G . Comparative pharmacokinetics of coumarin anticoagulants. X. Relationship between distribution, elimination, and anticoagulant action of warfarin. J Pharm Sci. 1974; 63(6):868-72. DOI: 10.1002/jps.2600630613. View

Hewick D . The plasma half-lives of the enantiomers of warfarin in warfarin-resistant and warfarin-susceptible rats. J Pharm Pharmacol. 1972; 24(8):661-2. DOI: 10.1111/j.2042-7158.1972.tb09083.x. View

Lewis R, Ilnicki L, Carlstrom M . The assay of warfarin in plasma or stool. Biochem Med. 1970; 4(5):376-82. DOI: 10.1016/0006-2944(70)90065-7. View

Wingard Jr L, Levy G . Kinetics of anticoagulant effect of dicumarol in rats. J Pharmacol Exp Ther. 1973; 184(1):253-60. View

Levy G, Yacobi A . Letter: Effect of plasma protein binding on elimination of warfarin. J Pharm Sci. 1974; 63(5):805-6. DOI: 10.1002/jps.2600630539. View

Jahnchen E, Wingard Jr L, Levy G . Effect of phenylbutazone on the distribution, elimination and anticoagulant action of dicumarol in rats. J Pharmacol Exp Ther. 1973; 187(1):176-84. View

10.

Goding L, West B . Synthesis and relative urinary excretion rates of the enantiomers of warfarin-4-14C and phenprocoumon-2-14C. J Med Chem. 1969; 12(3):517-8. DOI: 10.1021/jm00303a609. View

11.

Nagashima R, OReilly R, Levy G . Kinetics of pharmacologic effects in man: the anticoagulant action of warfarin. Clin Pharmacol Ther. 1969; 10(1):22-35. DOI: 10.1002/cpt196910122. View

12.

Breckenridge A, Orme M . The plasma half lives and the pharmacological effect of the enantiomers of warfarin in rats. Life Sci II. 1972; 11(7):337-45. DOI: 10.1016/0024-3205(72)90073-2. View

13.

Hurwitz A . A simple method for obtaining blood samples from rats. J Lab Clin Med. 1971; 78(1):172-4. View