Plasma Alkaline Phosphatase Isoenzymes in Hepatobiliary Disease

Overview

Journal J Clin Pathol

Specialty Pathology

Date 1974 Nov 1

PMID 4443409

Citations 2

Authors

A O Afonija

D N Baron

Affiliations

Soon will be listed here.

Abstract

BY CELLULOSE ACETATE OR ACRYLAMIDE GEL ELECTROPHORESIS IT IS POSSIBLE TO SEPARATE THESE ALKALINE PHOSPHATASE ISOENZYMES FROM SERUM: [anode] fast liver, slow liver, placenta/Regan, bone, intestine, bile [cathode]. Heat or chemical inhibition can confirm the differentiation. Normal adult serum always contains slow-liver isoenzyme, and sometimes bone isoenzyme: the latter is always present in serum of children. In hepatobiliary disease slow-liver isoenzyme was always increased: intestinal isoenzyme appeared in many cases of cirrhosis (of blood groups B and 0) but fast-liver and bile isoenzymes were occasionally seen in miscellaneous cases. The findings in other diseases included Regan isoenzyme in six out of 45 cases of malignant disease.

Citing Articles

Polyacrylamide gel disc electrophoresis of alkaline phosphatase isoenzymes in bone and liver disease.

Warnes T, Hine P, Kay G J Clin Pathol. 1976; 29(9):782-7.

PMID: 977779 PMC: 476179. DOI: 10.1136/jcp.29.9.782.

Clinical significance of an ultrafast alkaline phosphatase isoenzyme.

Koett J, Howell J, Wolf P J Clin Pathol. 1979; 32(12):1286-92.

PMID: 536464 PMC: 1145952. DOI: 10.1136/jcp.32.12.1286.

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