Pruritic Effect of Bile Salts

Overview

Journal Br Med J

Specialty General Medicine

Date 1974 Dec 21

PMID 4441863

Citations 22

Authors

J Kirby

K W Heaton

J L Burton

Affiliations

Soon will be listed here.

Abstract

The pruritic effect of purified bile salts has been tested by applying them to blister bases. All the salts tested were pruritogens, but the dihydroxy salts (especially unconjugated chenodeoxycholate) were more effective than the trihydroxy salts. This may explain the poor correlation between total serum bile salt concentration and pruritus in obstructive jaundice.

Citing Articles

Serum Bile Acid Profiling and Mixed Model Analysis Reveal Biomarkers Associated with Pruritus Reduction in Maralixibat-Treated Patients with BSEP Deficiency.

Zhao X, Zhang W, Vig P, Kostrub C, Setchell K Metabolites. 2022; 12(10).

PMID: 36295854 PMC: 9609791. DOI: 10.3390/metabo12100952.

MRGPRX4 is a bile acid receptor for human cholestatic itch.

Yu H, Zhao T, Liu S, Wu Q, Johnson O, Wu Z Elife. 2019; 8.

PMID: 31500698 PMC: 6773440. DOI: 10.7554/eLife.48431.

MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus.

Meixiong J, Vasavda C, Snyder S, Dong X Proc Natl Acad Sci U S A. 2019; 116(21):10525-10530.

PMID: 31068464 PMC: 6535009. DOI: 10.1073/pnas.1903316116.

Cholestatic pruritus: Emerging mechanisms and therapeutics.

Patel S, Vasavda C, Ho B, Meixiong J, Dong X, Kwatra S J Am Acad Dermatol. 2019; 81(6):1371-1378.

PMID: 31009666 PMC: 7825249. DOI: 10.1016/j.jaad.2019.04.035.

TRP Channels as Drug Targets to Relieve Itch.

Xie Z, Hu H Pharmaceuticals (Basel). 2018; 11(4).

PMID: 30301231 PMC: 6316386. DOI: 10.3390/ph11040100.

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