Peroxidatic Oxidation of Tyrosine to Melanin in Supernatant of Crude Mouse Melanoma Homogenates

Overview

Journal Biochem J

Specialty Biochemistry

Date 1974 Aug 1

PMID 4441386

Citations 1

Authors

R P Patel

M R OKUN

L M Edelstein

N Cariglia

Affiliations

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Abstract

Peroxide-dependent enzymic oxidation of tyrosine to dopachrome and melanin was demonstrated in cell-free melanoma homogenates. Histochemical methods for distinguishing peroxidase activity from aerobic dopa (3,4-dihydroxyphenylalanine) oxidase activity are not reliable with cell-free preparations. Therefore the presence of peroxidase activity in such preparations precludes assay of cresolase activity of mammalian ;tyrosinase'.

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Pomerantz S, Ances I J Clin Invest. 1975; 55(5):1127-31.

PMID: 804495 PMC: 301860. DOI: 10.1172/JCI108014.

References

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