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Cell-mediated Immunity to Intrinsic Factor in Autoimmune Disorders

Overview
Journal Br Med J
Specialty General Medicine
Date 1974 Nov 30
PMID 4434116
Citations 2
Authors
D James
G Asherson
I Chanarin
N Coghill
S Hamilton
R L HIMSWORTH
D Webster
Affiliations
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Abstract

Evidence of cell-mediated immunity to gastric intrinsic factor was present in 86% of patients with pernicious anaemia and in at least 13% of patients with hyperthyroidism, 21% of patients with atrophic gastritis, and four out of nine (46%) patients with hypogammaglobulinaemia. Controls gave negative results. The four patients with hypogammaglobulinaemia and cell-mediated immunity to intrinsic factor had evidence of impaired gastric function.

Citing Articles

Gastritis.

STRICKLAND R Springer Semin Immunopathol. 1990; 12(2-3):203-17.

PMID: 2205940 DOI: 10.1007/BF00197506.

Detection of cellular immunity derangements in chronic gastritis by a skin window test.

Ito H, Pitchumoni C, GLASS G Am J Dig Dis. 1978; 23(10):919-24.

PMID: 362903 DOI: 10.1007/BF01072467.

References
1.
ELLENBOGEN L, HIGHLEY D . Hog intrinsic factor. I. Isolation of vitamin B12-binding fractions from hog pylorus. J Biol Chem. 1967; 242(5):1004-9. View
2.
Douglas S, Goldberg L, Fudenberg H, Goldberg S . Agammaglobulinaemia and co-existent pernicious anaemia. Clin Exp Immunol. 1970; 6(2):181-7. PMC: 1712785. View
3.
TWOMEY J, JORDAN Jr P, Laughter A, Meuwissen H, GOOD R . The gastric disorder in immunoglobulin-deficient patients. Ann Intern Med. 1970; 72(4):499-504. DOI: 10.7326/0003-4819-72-4-499. View
4.
Ginsberg A, MULLINAX F . Pernicious anemia and monoclonal gammopathy in a patient with IgA deficiency. Am J Med. 1970; 48(6):787-91. DOI: 10.1016/s0002-9343(70)80015-8. View
5.
Rose M, Doniach D, Chanarin I, Brostoff J, Ardeman S . Intrinsic-factor antibodies in absence of pernicious anaemia. 3-7 year follow-up. Lancet. 1970; 2(7662):9-12. DOI: 10.1016/s0140-6736(70)92473-6. View