SK&F 92657, a Novel Antihypertensive Acting by Precapillary Vasodilatation and Beta-adrenoreceptor Blockade

Overview

Journal Clin Sci (Lond)

Specialties Biochemistry
General Medicine
Science

Date 1979 Dec 1

PMID 44235

Citations 12

Authors

E M Taylor

A M Roe

R A Slater

Affiliations

Soon will be listed here.

Abstract

1. The properties of a new antihypertensive agent, SK&F 92657, DL-3-[2-(3-t-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazinopyridazine, have been studied. 2. The compound caused a sustained fall in blood pressure in several species as a result of precapillary vasodilatation, particularly in the renal and coronary vasculatures. 3. The beta-adrenoreceptor-blocking actions of SK&F 92657 prevent reflex cadiac stimulation.

Citing Articles

Cardiovascular effects in man of intravenous prizidilol hydrochloride (SK&F 92657); a new antihypertensive agent.

EDMONSTONE W, Manghani K, Bell A, McLeod M, Burland W Br J Clin Pharmacol. 1981; 12(4):567-72.

PMID: 7295490 PMC: 1401881. DOI: 10.1111/j.1365-2125.1981.tb01266.x.

Metal binding by pharmaceuticals. Part 4. A comparative investigation of the interaction of metal ions with hydralazine, prizidilol and related compounds.

May P, Roe A, Slater R, Trott W, Williams D Agents Actions. 1984; 14(1):113-20.

PMID: 6702508 DOI: 10.1007/BF01966843.

Cardiovascular response to exercise and regional haemodynamics during treatment with prizidilol hydrochloride (SK & F 92 657) in moderately severe essential hypertension.

Andersson O, Ljungman S, Berglund G Eur J Clin Pharmacol. 1983; 25(5):577-80.

PMID: 6662157 DOI: 10.1007/BF00542341.

Pulmonary effects in man of oral prizidilol hydrochloride (SK&F 92657), a new antihypertensive agent.

EDMONDSTONE W, Waller J, Manghani K, Hill P, Bell A, DENISON D Br J Clin Pharmacol. 1983; 16(6):591-8.

PMID: 6140939 PMC: 1428340. DOI: 10.1111/j.1365-2125.1983.tb02227.x.

Prizidilol, a combined vasodilatory and beta-adrenoceptor blocking drug, in primary hypertension. A long-term efficacy, tolerance and pharmacokinetic study.

Karlberg B, Larsson R, Ohman K, Norlander B, Wirsen A, Hed J Eur J Clin Pharmacol. 1983; 25(2):179-86.

PMID: 6138257 DOI: 10.1007/BF00543788.