Synthesis of Inducible Tyrosine Aminotransferase in a Cell-free Extract from Cultured Hepatoma Cells

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1972 Dec 1

PMID 4405028

Citations 9

Authors

J P Beck

G Beck

K Y Wong

G M Tomkins

Affiliations

Soon will be listed here.

Abstract

A cell-free extract from cultured rat hepatoma cells is described that incorporates amino acids into chains of tyrosine aminotransferase that are identical, by several criteria, with tyrosine aminotransferase from rat liver. Extracts from steroid-induced cells are 6-to 10-times more active for tyrosine aminotransferase synthesis than extracts from uninduced cells, although the total incorporation rates are identical.

Citing Articles

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Messenger RNA for hepatic tryptophan oxygenase: its partial purification, its translation in a heterologous cell-free system, and its control by glucocorticoid hormones.

Schutz G, Beato M, FEIGELSON P Proc Natl Acad Sci U S A. 1973; 70(4):1218-21.

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Specific changes in the messenger ribonucleic acid content of the rat ventral prostate gland after androgenic stimulation. Evidence from the synthesis of aldolase messenger ribonucleic acid.

MAINWARING W, Mangan F, Irving R, Jones D Biochem J. 1974; 144(2):413-26.

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Synthesis of phosphoenolpyruvate carboxykinase (guanosine triphosphate) by isolated liver polyribosomes.

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References

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