The Effects of Calcium and Magnesium on Statistical Release Parameters at the Crayfish Neuromuscular Junction

Overview

Journal J Physiol

Specialty Physiology

Date 1972 Nov 1

PMID 4404687

Citations 21

Authors

A Wernig

Affiliations

Soon will be listed here.

Abstract

1. Transmitter release at excitatory neuromuscular junctions of crayfish muscle was studied at low temperature by recording synaptic potentials with extracellular micro-electrodes.2. Increasing the Ca concentration in the bathing solution produced an increase in the average number of quanta released per nerve stimulus (m). Increasing the Mg concentration resulted in a decrease in m.3. Statistical analysis of fluctuations in the quantal release from trial to trial, assuming binomial statistics, indicated that both the changes in m were due to changes in the average quantal release probability (p).

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References

Thies R . NEUROMUSCULAR DEPRESSION AND THE APPARENT DEPLETION OF TRANSMITTER IN MAMMALIAN MUSCLE. J Neurophysiol. 1965; 28(3):427-42. DOI: 10.1152/jn.1965.28.3.427. View

Rahamimoff R . A dual effect of calcium ions on neuromuscular facilitation. J Physiol. 1968; 195(2):471-80. PMC: 1351673. DOI: 10.1113/jphysiol.1968.sp008468. View

Bracho H, ORKAND R . Effect of calcium on excitatory neuromuscular transmission in the crayfish. J Physiol. 1970; 206(1):61-71. PMC: 1348586. DOI: 10.1113/jphysiol.1970.sp008997. View

Betz W . Depression of transmitter release at the neuromuscular junction of the frog. J Physiol. 1970; 206(3):629-44. PMC: 1348669. DOI: 10.1113/jphysiol.1970.sp009034. View

Katz B, Miledi R . The timing of calcium action during neuromuscular transmission. J Physiol. 1967; 189(3):535-44. PMC: 1396115. DOI: 10.1113/jphysiol.1967.sp008183. View

Christensen B, Martin A . Estimates of probability of transmitter release at the mammalian neuromuscular junction. J Physiol. 1970; 210(4):933-45. PMC: 1395639. DOI: 10.1113/jphysiol.1970.sp009250. View

ELMQVIST D, QUASTEL D . A quantitative study of end-plate potentials in isolated human muscle. J Physiol. 1965; 178(3):505-29. PMC: 1357310. DOI: 10.1113/jphysiol.1965.sp007639. View

Baker P, HODGKIN A, Ridgway E . Depolarization and calcium entry in squid giant axons. J Physiol. 1971; 218(3):709-55. PMC: 1331609. DOI: 10.1113/jphysiol.1971.sp009641. View

Bittner G . Differentiation of nerve terminals in the crayfish opener muscle and its functional significance. J Gen Physiol. 1968; 51(6):731-58. PMC: 2201236. DOI: 10.1085/jgp.51.6.731. View

10.

LILEY A, NORTH K . An electrical investigation of effects of repetitive stimulation on mammalian neuromuscular junction. J Neurophysiol. 1953; 16(5):509-27. DOI: 10.1152/jn.1953.16.5.509. View

11.

Katz B, Miledi R . Further study of the role of calcium in synaptic transmission. J Physiol. 1970; 207(3):789-801. PMC: 1348742. DOI: 10.1113/jphysiol.1970.sp009095. View

12.

Johnson E, Wernig A . The binomial nature of transmitter release at the crayfish neuromuscular junction. J Physiol. 1971; 218(3):757-67. PMC: 1331610. DOI: 10.1113/jphysiol.1971.sp009642. View

13.

Takeuchi A . The long-lasting depression in neuromuscular transmission of frog. Jpn J Physiol. 1958; 8(2):102-13. DOI: 10.2170/jjphysiol.8.102. View

14.

Dodge Jr F, Rahamimoff R . Co-operative action a calcium ions in transmitter release at the neuromuscular junction. J Physiol. 1967; 193(2):419-32. PMC: 1365607. DOI: 10.1113/jphysiol.1967.sp008367. View

15.

Katz B, Miledi R . A study of synaptic transmission in the absence of nerve impulses. J Physiol. 1967; 192(2):407-36. PMC: 1365564. DOI: 10.1113/jphysiol.1967.sp008307. View

16.

Katz B, Miledi R . The role of calcium in neuromuscular facilitation. J Physiol. 1968; 195(2):481-92. PMC: 1351674. DOI: 10.1113/jphysiol.1968.sp008469. View

17.

Del Castillo J, Katz B . Quantal components of the end-plate potential. J Physiol. 1954; 124(3):560-73. PMC: 1366292. DOI: 10.1113/jphysiol.1954.sp005129. View

18.

Katz B, Miledi R . The release of acetylcholine from nerve endings by graded electric pulses. Proc R Soc Lond B Biol Sci. 1967; 167(1006):23-38. DOI: 10.1098/rspb.1967.0011. View

19.

Lundberg A, QUILISCH H . Presynaptic potentiation and depression of neuromuscular transmission in frog and rat. Acta Physiol Scand Suppl. 1953; 111:111-20. View

20.

Katz B, Miledi R . The effect of temperature on the synaptic delay at the neuromuscular junction. J Physiol. 1965; 181(3):656-70. PMC: 1357674. DOI: 10.1113/jphysiol.1965.sp007790. View