Immunocompetent Cells Among Mouse Thymocytes: a Minor Population

Overview

Journal Science

Specialty Science

Date 1971 Jun 18

PMID 4396965

Citations 22

Authors

E LECKBAND

E A Boyse

Affiliations

Soon will be listed here.

Abstract

Suspensions prepared from thymuses of TL(+) mice contain a majority of TL(+) cells and a minority of TL(-) cells. The graft versus host reactivity of the TL(-) population is much greater than that of the whole population, as judged by the numbers of cells required to give splenic enlargements in Simonsen's assay. It is proposed that the TL(-) thymocyte represents a stage in the differentiation of TL(+) thymocytes into immunocompetent lymphocytes.

Citing Articles

Specific heterologous enhancement of immune responses. II. Immunological memory cells of thymic origin.

Rubin A, Coons A J Exp Med. 1972; 135(2):437-41.

PMID: 5060295 PMC: 2180519. DOI: 10.1084/jem.135.2.437.

Potentiation of the T-lymphocyte response to mitogens. I. The responding cell.

Gery I, GERSHON R, Waksman B J Exp Med. 1972; 136(1):128-42.

PMID: 5033417 PMC: 2139184. DOI: 10.1084/jem.136.1.128.

Antibody formation in mouse bone marrow. III. Effects of route of priming and antigen dose.

Benner R, Meima F, van der Meulen G, van Ewijk W Immunology. 1974; 27(5):747-60.

PMID: 4611907 PMC: 1445672.

Separation and characterization of cell subpopulations in the thymus.

Sabolovic D, Dumont F Immunology. 1973; 24(4):601-6.

PMID: 4574795 PMC: 1422914.

Functional maturation of thymic lymphocyte populations in vitro.

Mosier D, Pierce C J Exp Med. 1972; 136(6):1484-500.

PMID: 4565838 PMC: 2139328. DOI: 10.1084/jem.136.6.1484.