The Intermediary Role of a 19-oxoandrogen in the Biosynthesis of Oestrogen

Overview

Journal Biochem J

Specialty Biochemistry

Date 1968 Sep 1

PMID 4386500

Citations 9

Authors

M Akhtar

S J Skinner

Affiliations

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Citing Articles

Kinetic solvent isotope effect in steady-state turnover by CYP19A1 suggests involvement of Compound 1 for both hydroxylation and aromatization steps.

Khatri Y, Luthra A, Duggal R, Sligar S FEBS Lett. 2014; 588(17):3117-22.

PMID: 24997347 PMC: 4138292. DOI: 10.1016/j.febslet.2014.06.050.

The structural biology of oestrogen metabolism.

Thomas M, Potter B J Steroid Biochem Mol Biol. 2013; 137:27-49.

PMID: 23291110 PMC: 3866684. DOI: 10.1016/j.jsbmb.2012.12.014.

Mechanistic and stereochemical studies on 3-oxo steroid delta 4-delta 5-isomerase from human placenta.

Akhtar M, Calder M, Smith T, Wright J Biochem J. 1980; 185(2):411-21.

PMID: 7396823 PMC: 1161368. DOI: 10.1042/bj1850411.

Mechanistic studies on C-19 demethylation in oestrogen biosynthesis.

Akhtar M, Calder M, Corina D, Wright J Biochem J. 1982; 201(3):569-80.

PMID: 7092812 PMC: 1163683. DOI: 10.1042/bj2010569.

The stereospecific removal of a C-19 hydrogen atom in oestrogen biosynthesis.

Skinner S, Akhtar M Biochem J. 1969; 114(1):75-81.

PMID: 5810071 PMC: 1184798. DOI: 10.1042/bj1140075.

References

Akhtar M, Parvez M, HUNT P . The introduction of the C-22-C-23 ethylenic linkage in ergosterol biosynthesis. Biochem J. 1968; 106(3):623-6. PMC: 1198551. DOI: 10.1042/bj1060623. View

Meyer A . Conversion of 19-hydroxy-delta 4-androstene-3,17-dione to estrone by endocrine tissue. Biochim Biophys Acta. 1955; 17(3):441-2. DOI: 10.1016/0006-3002(55)90395-4. View

Ryan K . Biological aromatization of steroids. J Biol Chem. 1959; 234(2):268-72. View

Morato T, Hayano M, Dorfman R, AXELROD L . The intermediate steps in the biosynthesis of estrogens from androgens. Biochem Biophys Res Commun. 1961; 6:334-8. DOI: 10.1016/0006-291x(61)90140-1. View

LONGCHAMPT J, GUAL C, EHRENSTEIN M, Dorfman R . 19-Hydroxy-delta 4-androstene-3,17-dione, an intermediate in estrogen biosynthesis. Endocrinology. 1960; 66:416-9. DOI: 10.1210/endo-66-3-416. View