Estrogen-related Increases in Uterine Guanosine 3':5'-cyclic Momophosphate Levels

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1974 May 1

PMID 4365763

Citations 19

Authors

F A KUEHL Jr

E A HAM

M E Zanetti

C H SANFORD

S E Nicol

N D Goldberg

Affiliations

Soon will be listed here.

Abstract

Endogenous uterine cyclic GMP and cyclic AMP concentrations were monitored at each stage of the estrus cycle; cyclic GMP concentrations were found to be highest and cyclic AMP concentrations lowest during proestrus when plasma estrogen levels have been shown to be maximal. After administration of estradiol-17beta or diethylstilbestrol, the concentrations of uterine cyclic GMP in ovariectomized rats underwent a progressive and significant elevation and the levels of cyclic AMP declined significantly below control values when near maximal accumulation of tissue cyclic GMP was achieved. The increase in uterine cyclic GMP concentrations produced by estradiol benzoate administration was prevented when progesterone and the estrogen were co-administered. These results raise the possibility that an enhanced cellular accumulation of cyclic GMP may be involved in the expression of some of the actions of estrogen in uterine tissue.

Citing Articles

Intracellular and Extracellular Cyclic Nucleotides in Wild-Type and White Collar Mutant Strains of Neurospora crassa: Temperature Dependent Efflux of Cyclic AMP from Mycelia.

Shaw N, Harding R Plant Physiol. 1987; 83(2):377-83.

PMID: 16665253 PMC: 1056365. DOI: 10.1104/pp.83.2.377.

Estradiol rapidly inhibits soluble guanylyl cyclase expression in rat uterus.

Krumenacker J, Hyder S, Murad F Proc Natl Acad Sci U S A. 2001; 98(2):717-22.

PMID: 11209068 PMC: 14654. DOI: 10.1073/pnas.98.2.717.

Loirand G, Cario-Toumaniantz C, Chardin P, Pacaud P J Physiol. 1999; 516 ( Pt 3):825-34.

PMID: 10200428 PMC: 2269299. DOI: 10.1111/j.1469-7793.1999.0825u.x.

Non-genomic mechanism of 17 beta-oestradiol-induced inhibition of contraction in mammalian vascular smooth muscle.

Kitazawa T, Hamada E, Kitazawa K, Gaznabi A J Physiol. 1997; 499 ( Pt 2):497-511.

PMID: 9080377 PMC: 1159322. DOI: 10.1113/jphysiol.1997.sp021944.

Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription.

Aronica S, Kraus W, Katzenellenbogen B Proc Natl Acad Sci U S A. 1994; 91(18):8517-21.

PMID: 8078914 PMC: 44637. DOI: 10.1073/pnas.91.18.8517.

References

Goldberg N, Passonneau J, LOWRY O . Effects of changes in brain metabolism on the levels of citric acid cycle intermediates. J Biol Chem. 1966; 241(17):3997-4003. View

Hardman J, Davis J, SUTHERLAND E . Measurement of guanosine 3',5'-monophosphate and other cyclic nucleotides. Variations in urinary excretion with hormonal state of the rat. J Biol Chem. 1966; 241(20):4812-5. View

SZEGO C, Davis J . Adenosine 3',5'-monophosphate in rat uterus: acute elevation by estrogen. Proc Natl Acad Sci U S A. 1967; 58(4):1711-8. PMC: 223984. DOI: 10.1073/pnas.58.4.1711. View

Goldberg N, Dietz S, OToole A . Cyclic guanosine 3',5'-monophosphate in mammalian tissues and urine. J Biol Chem. 1969; 244(16):4458-66. View

Hardman J, Davis J, SUTHERLAND E . Effects of some hormonal and other factors on the excretion of guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate in rat urine. J Biol Chem. 1969; 244(23):6354-62. View

GILMAN A . A protein binding assay for adenosine 3':5'-cyclic monophosphate. Proc Natl Acad Sci U S A. 1970; 67(1):305-12. PMC: 283204. DOI: 10.1073/pnas.67.1.305. View

Milgrom E, Atger M, Baulieu E . Progesterone in uterus and plasma. IV. Progesterone receptor(s) in guinea pig uterus cytosol. Steroids. 1970; 16(6):741-54. DOI: 10.1016/s0039-128x(70)80152-0. View

Murad F, Manganiello V, Vaughan M . A simple, sensitive protein-binding assay for guanosine 3':5'-monophosphate. Proc Natl Acad Sci U S A. 1971; 68(4):736-9. PMC: 389031. DOI: 10.1073/pnas.68.4.736. View

Steiner A, PAGLIARA A, CHASE L, KIPNIS D . Radioimmunoassay for cyclic nucleotides. II. Adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in mammalian tissues and body fluids. J Biol Chem. 1972; 247(4):1114-20. View

10.

Hadden J, Hadden E, Haddox M, Goldberg N . Guanosine 3':5'-cyclic monophosphate: a possible intracellular mediator of mitogenic influences in lymphocytes. Proc Natl Acad Sci U S A. 1972; 69(10):3024-7. PMC: 389699. DOI: 10.1073/pnas.69.10.3024. View

11.

JENSEN E, Desombre E . Mechanism of action of the female sex hormones. Annu Rev Biochem. 1972; 41:203-30. DOI: 10.1146/annurev.bi.41.070172.001223. View

12.

Sanborn B, Bhalla R, Korenman S . Use of a modified radioligand assay to measure the effect of estradiol on uterine adenosine 3',5'-cyclic monophosphate. Endocrinology. 1973; 92(2):494-9. DOI: 10.1210/endo-92-2-494. View

13.

SZEGO C . Lysosomal membrane stabilization and antiestrogen action in specific hormonal target cells. Gynecol Invest. 1972; 3(1):63-95. DOI: 10.1159/000301745. View

14.

Saksena S, HARPER M . Levels of F prostaglandin (PGF) in uterine tissue during the estrous cycle of hamster: effects of estradiol and progesterone. Prostaglandins. 1972; 2(5):405-11. DOI: 10.1016/s0090-6980(72)80048-0. View

15.

Kram R, Tomkins G . Pleiotypic control by cyclic AMP: interaction with cyclic GMP and possible role of microtubules. Proc Natl Acad Sci U S A. 1973; 70(6):1659-63. PMC: 433567. DOI: 10.1073/pnas.70.6.1659. View

16.

Schultz G, Hardman J, Schultz K, Davis J, SUTHERLAND E . A new enzymatic assay for guanosine 3':5'-cyclic monophosphate and its application to the ductus deferens of the rat. Proc Natl Acad Sci U S A. 1973; 70(6):1721-5. PMC: 433581. DOI: 10.1073/pnas.70.6.1721. View

17.

JENSEN E, Desombre E . Estrogen-receptor interaction. Science. 1973; 182(4108):126-34. DOI: 10.1126/science.182.4108.126. View

18.

Sim M, Chatharaksri U . Rat uterine contractility and the activities of uterine adenyl cyclase and phosphodiesterase during the estrus cycle. Biochem Pharmacol. 1973; 22(12):1417-22. DOI: 10.1016/0006-2952(73)90319-5. View

19.

Iacobelli S . Induced protein synthesis and oestradiol binding to the nuclei in the rat uterus. Nat New Biol. 1973; 245(144):154-5. DOI: 10.1038/newbio245154a0. View

20.

Shaikh A . Estrone and estradiol levels in the ovarian venous blood from rats during the estrous cycle and pregnancy. Biol Reprod. 1971; 5(3):297-307. DOI: 10.1093/biolreprod/5.3.297. View