Transformation of Cultured Mammalian Cells by Viable Herpes Simplex Virus Subtypes 1 and 2

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1974 Jan 1

PMID 4359329

Citations 11

Authors

B Garfinkle

B R McAuslan

Affiliations

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Abstract

A continuous line of rodent cells carrying the genome of the Rous sarcoma virus was stably transformed by exposure to viable herpes simplex virus of either subtype 1 or 2. Transformation was accompanied by alteration of morphology, growth characteristics, acquisition of a thymidine kinase activity (EC 2.7.1.21) resembling the corresponding specific activity of the enzyme in the herpes simplex virus, and capacity to express continuously some antigens specific for herpes simplex virus.

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