MHPG Excretion in Depressive Disorders: Relation to Clinical Subtypes and Desynchronized Sleep

Overview

Journal Science

Specialty Science

Date 1973 Aug 24

PMID 4353428

Citations 3

Authors

J J Schildkraut

B A Keeler

M Papousek

E Hartmann

Affiliations

Soon will be listed here.

Abstract

The urinary excretion of 3-methoxy-4-hydroxyphenylglycol (MHPG) was significantly lower in patients with manic-depressive depressions than in patients with chronic characterological depressions. There was an inverse relationship between MHPG excretion and the amount of time spent in desynchronized sleep, particularly in the manic-depressive disorders. Excretion of MHPG was not related to the degree of retardation, agitation, or anxiety in these patients.

Citing Articles

Psychotherapeutic drugs and biogenic amines. Current concepts and therapeutic implications.

Potter W Drugs. 1984; 28(2):127-43.

PMID: 6205841 DOI: 10.2165/00003495-198428020-00003.

Determination of 3-methoxy-4-hydroxyphenylglycol conjugates in urine. Application to the study of central noradrenaline metabolism in unmedicated chronic schizophrenic patients.

Joseph M, Baker H, Johnstone E, Crow T Psychopharmacology (Berl). 1976; 51(1):47-51.

PMID: 827775 DOI: 10.1007/BF00426320.

Fluvoxamine-a new serotonin re-uptake inhibitor: first clinical and psychometric experiences in depressed patients.

Saletu B, Schjerve M, Grunberger J, Schanda H, Arnold O J Neural Transm. 1977; 41(1):17-36.

PMID: 335026 DOI: 10.1007/BF01252962.