Determination of Natural Host Taxonomy of RNA Tumor Viruses by Molecular Hybridization: Application to RD-114, a Candidate Human Virus

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1973 May 1

PMID 4351179

Citations 19

Authors

R M Ruprecht

N C Goodman

S Spiegelman

Affiliations

Soon will be listed here.

Abstract

The lysogenic bacteriophages and the RNA tumor viruses have in common the ability to add their genetic information to the genome of their host cells. The biological similarity extends further; data summarized here indicate that they both possess homology to the DNA of their uninfected indigenous hosts. Sharing of common sequences with normal host DNA has been established with avian, murine, feline, and primate oncornaviruses. This finding provides a method for determining the taxonomic position of the natural host of any new RNA tumor virus isolated. Application of this approach to RD-114 revealed extensive hybridization to normal cat DNA and little, if any, hybridization to human DNA. We conclude that the data assign a feline origin rather than a human origin to RD-114.

Citing Articles

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The presence of unique DNA sequences after viral induction of leukemia in mice. (RNA tumor virus-nucleic acid hybridization-insertion of viral DNA).

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Structure and molecular length of the large subunits of RD-114 viral RNA.

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Detection of baboon type C viral sequences in various primate tissues by molecular hybridization.

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