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Herpesvirus Hominis Type 2 Infections in Rabbits: Effect of Prior Immunization with Attenuated Mycobacterium Bovis (BCG) Cells

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Journal Infect Immun
Date 1972 Oct 1
PMID 4344024
Citations 13
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Abstract

Angora, New Zealand, and Dutch-belted rabbits were tested for their susceptibility to graded doses of Herpesvirus hominis type 2 administered by vaginal instillation, intracorneal injection, and scarification of the cornea. Central nervous system involvement and death occurred after infection by the various routes employed. Prior immunization of Dutch-belted and New Zealand rabbits with viable Mycobacterium bovis (BCG) cells injected intravenously provided protection against subsequent infections with type 2 virus.

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