Studies on the Control of Cholesterol Biosynthesis: the Adenosine 3':5'-cyclic Monophosphate-dependent Accumulation of a Steroid Carboxylic Acid

Overview

Journal Biochem J

Specialty Biochemistry

Date 1971 Jun 1

PMID 4331371

Citations 5

Authors

D P Bloxham

M Akhtar

Affiliations

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Citing Articles

Studies on the mechanism and regulation of C-4 demethylation in cholesterol biosynthesis. The role of adenosine 3':5'-cyclic monophosphate.

Bloxham D, Wilton D, Akhtar M Biochem J. 1971; 125(2):625-34.

PMID: 4401381 PMC: 1178100. DOI: 10.1042/bj1250625.

Anti-anabolic effects of adenosine 3':5'-cyclic monophosphate. Inhibition of protein synthesis.

Sellers A, Bloxham D, MUNDAY K, Akhtar M Biochem J. 1974; 138(3):335-40.

PMID: 4372990 PMC: 1166218. DOI: 10.1042/bj1380335.

Selective inhibition of cholesterol synthesis by cell-free preparations of rat liver by using inhibitors of cytoplasmic acetoacetyl-coenzyme A thiolase.

Bloxham D Biochem J. 1975; 147(3):531-9.

PMID: 241330 PMC: 1165481. DOI: 10.1042/bj1470531.

Effects of glucagon and insulin on fatty acid synthesis and glycogen degradation in the perfused liver of normal and genetically obese (ob/ob) mice.

Ma G, Gove C, HEMS D Biochem J. 1978; 174(3):761-8.

PMID: 31866 PMC: 1185980. DOI: 10.1042/bj1740761.

Chemical and enzymic studies on the characterization of intermediates during the removal of the 14alpha-methyl group in cholesterol biosynthesis. The use of 32-functionalized lanostane derivatives.

Akhtar M, Alexander K, Boar R, McGHIE J, Barton D Biochem J. 1978; 169(3):449-63.

PMID: 25646 PMC: 1183817. DOI: 10.1042/bj1690449b.

References

CORNFORTH J, CORNFORTH R, POPJAK G, Yengoyan L . Studies on the biosynthesis of cholesterol. XX. Steric course of decarboxylation of 5-pyrophosphomevalonate and of the carbon to carbon bond formation in the biosynthesis of farnesyl pyrophosphate. J Biol Chem. 1966; 241(17):3970-87. View

Akhtar M, HUNT P, Parvez M . The transfer of hydrogen from C-24 to C-25 in ergosterol biosynthesis. Biochem J. 1967; 103(3):616-22. PMC: 1270458. DOI: 10.1042/bj1030616. View

Wilton D, MUNDAY K, Skinner S, Akhtar M . The biological conversion of 7-dehydrocholesterol into cholesterol and comments on the reduction of double bonds. Biochem J. 1968; 106(4):803-10. PMC: 1198583. DOI: 10.1042/bj1060803. View

Canonica L, Fiecchi A, Kienle M, Scala A, Galli G, Paoletti E . The biological conversion of 5alpha-cholest-8-en-3beta-ol to 5alpha-cholest-7-en-3beta-ol in the biosynthesis of cholesterol. Steroids. 1968; 11(3):287-98. DOI: 10.1016/s0039-128x(68)80141-2. View

Canonica L, Fiecchi A, Kienle M, Scala A, Galli G, Paoletti E . The fate of the 15-beta hydrogen of lanosterol in cholesterol biosynthesis. J Am Chem Soc. 1968; 90(13):3597-8. DOI: 10.1021/ja01015a074. View

Caspi E, Greig J, Ramm P, Varma K . Stereochemistry of tritium at C-1 and C-7 in cholesterol derived from (3R,2R)-2T-mevalonic acid. Tetrahedron Lett. 1968; (35):3829-32. DOI: 10.1016/s0040-4039(01)99112-9. View

Robison G, Butcher R, SUTHERLAND E . Cyclic AMP. Annu Rev Biochem. 1968; 37:149-74. DOI: 10.1146/annurev.bi.37.070168.001053. View

Swindell A, Gaylor J . Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3-ketosteroid intermediates. J Biol Chem. 1968; 243(21):5546-55. View

Akhtar M, Rahimtula A, Watkinson I, Wilton D, MUNDAY K . The status of C-6, C-7, C-15 and C-16 hydrogen atoms in cholesterol biosynthesis. Eur J Biochem. 1969; 9(1):107-11. DOI: 10.1111/j.1432-1033.1969.tb00582.x. View

10.

Akhtar M, Rahimtula A, Wilton D . The incorporation of a hydrogen atom at C-15 of cholesterol biosynthesized from squalene. Biochem J. 1969; 114(4):801-6. PMC: 1184967. DOI: 10.1042/bj1140801. View

11.

Miller W, Gaylor J . Investigation of the component reactions of oxidative sterol demethylation. Oxidation of a 4 alpha-methyl sterol to a 4 alpha-carboxylic acid during cholesterol biosynthesis. J Biol Chem. 1970; 245(20):5369-74. View

12.

Miller W, Gaylor J . Investigation of the component reactions of oxidative sterol demethylation. Oxidation of a 4,4-dimethyl sterol to a 4 beta-methyl-4 alpha-carboxylic acid during cholesterol biosynthesis. J Biol Chem. 1970; 245(20):5375-81. View

13.

Hornby G, BOYD G . A carboxylic acid intermediate of lanostenol demethylation. Biochem Biophys Res Commun. 1970; 40(6):1452-4. DOI: 10.1016/0006-291x(70)90030-6. View

14.

Lindberg M, Gautschi F, Bloch K . Ketonic intermediates in the demethylation of lanosterol. J Biol Chem. 1963; 238:1661-4. View