The Synthesis of Nicotinamide-adenine Dinucleotide and Poly (adenosine Diphosphate Ribose) in Various Classes of Rat Liver Nuclei

Overview

Journal Biochem J

Specialty Biochemistry

Date 1969 Dec 1

PMID 4311824

Citations 5

Authors

M E. Haines

I R JOHNSTON

A P Mathias

D Ridge

Affiliations

Soon will be listed here.

Abstract

1. The activities of NMN adenylyltransferase and an enzyme that synthesizes poly (ADP-ribose) from NAD were investigated in the various classes of rat liver nuclei fractionated by zonal centrifugation. 2. The highest specific activities of these two nuclear enzymes occur in different classes of nuclei. In very young and in mature rats it was shown that a correlation exists between DNA synthesis and NMN adenylyltransferase activity, but in rats of intermediate age this correlation is less evident. The highest activities of the enzyme that catalyses formation of poly (ADP-ribose) are in the nuclei involved in the synthesis of RNA. 3. The significance of these results in relation to NAD metabolism is discussed.

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