Variation in Properties of Plaque Progeny of PARA (defective Simian Papovavirus 40)-adenovirus 7

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1969 Nov 1

PMID 4311794

Citations 16

Authors

F Rapp

S PAULUZZI

J S Butel

Affiliations

Soon will be listed here.

Abstract

One hundred and twelve progeny from double plaque-purified clones were derived from the original PARA (defective simian papovavirus 40)-adenovirus 7 population. These progeny were found to differ in their oncogenic potential in newborn hamsters with progeny from 20 clones not inducing any tumors during 1 year of observation. The varying tumorigenicity of the individual clonal progeny was not related to the titer of PARA (particle aiding replication of adenovirus) in the inoculum. There was a perfect correlation between the tumor antigen content of the tumor cells and the antibody response of the tumor-bearing host. The tumors containing both adenovirus and simian papovavirus 40 (SV40) tumor antigens appeared earlier than those carrying only SV40 tumor antigen. Progeny from clones which induced mixed tumors also produced tumors which contained only SV40 tumor antigen. Three variants of PARA were isolated which induced the synthesis of SV40 tumor antigen in the cytoplasm of infected simian cells; all other clones yielded progeny which induced synthesis of SV40 tumor antigen in the nucleus.

Citing Articles

Non-equivalence of nuclear import among nuclei in multinucleated skeletal muscle cells.

Cutler A, Jackson J, Corbett A, Pavlath G J Cell Sci. 2018; 131(3).

PMID: 29361530 PMC: 5826044. DOI: 10.1242/jcs.207670.

Density differences between hybrid and nonhybrid particles in two adenovirus-simian virus 40 hybrid populations.

Baum S, Wiese W, Rowe W J Virol. 1970; 5(3):353-7.

PMID: 16789126 PMC: 376012. DOI: 10.1128/JVI.5.3.353-357.1970.

Antigenic structure of simian virus 40 large tumor antigen and association with cellular protein p53 on the surfaces of simian virus 40-infected and -transformed cells.

Santos M, Butel J J Virol. 1984; 51(2):376-83.

PMID: 6205166 PMC: 254448. DOI: 10.1128/JVI.51.2.376-383.1984.

Biological and biophysical characterization of SV40 cytoplasmic T-antigen-inducing mutants of PARA-adenovirus 7.

Guentzel M, Butel J Arch Gesamte Virusforsch. 1973; 43(1):74-87.

PMID: 4367381 DOI: 10.1007/BF01249350.

Biochemical aspects of viral transformation.

Salzman N In Vitro. 1971; 6(5):349-54.

PMID: 4360733 DOI: 10.1007/BF02619072.

References

Butel J, Rapp F . Replication in simian cells of defective viruses in an SV40-adenovirus "hybrid" population. J Bacteriol. 1966; 91(1):278-84. PMC: 315946. DOI: 10.1128/jb.91.1.278-284.1966. View

Rapp F, Jerkofsky M, Melnick J, Levy B . Variation in the oncogenic potential of human adenoviruses carrying a defective SV40 genome (PARA). J Exp Med. 1968; 127(1):77-90. PMC: 2138431. DOI: 10.1084/jem.127.1.77. View

Rapp F, Melnick J, Butel J, Kitahara T . THE INCORPORATION OF SV40 MATERIAL INTO ADENOVIRUS 7 AS MEASURED BY INTRANUCLEAR SYNTHESIS OF SV40 TUMOR ANTIGEN. Proc Natl Acad Sci U S A. 1964; 52:1348-52. PMC: 300451. DOI: 10.1073/pnas.52.6.1348. View

Rapp F, Butel J, Tevethia S, Katz M, Melnick J . Antigenic analysis of tumors and sera from aimals inoculated with para-adenovirus populations. J Immunol. 1966; 97(6):833-9. View

HUEBNER R, Chanock R, RUBIN B, Casey M . INDUCTION BY ADENOVIRUS TYPE 7 OF TUMORS IN HAMSTERS HAVING THE ANTIGENIC CHARACTERISTICS OF SV40 VIRUS. Proc Natl Acad Sci U S A. 1964; 52:1333-40. PMC: 300449. DOI: 10.1073/pnas.52.6.1333. View

Black P, White B . In vitro transformation by the adenovirus-SV40 hybrid viruses. II. Characteristics of the transformation of hamster cells by the adeno 2-, adeno 3-, and adeno 12-SV40 viruses. J Exp Med. 1967; 125(4):629-46. PMC: 2138372. DOI: 10.1084/jem.125.4.629. View

Butel J, Guentzel M, Rapp F . Variants of defective simian papovavirus 40 (PARA) characterized by cytoplasmic localization of simian papovavirus 40 tumor antigen. J Virol. 1969; 4(5):632-41. PMC: 375919. DOI: 10.1128/JVI.4.5.632-641.1969. View

Boeye A, Melnick J, Rapp F . SV40-adenovirus "hybrids": presence of two genotypes and the requirement of their complementation for viral replication. Virology. 1966; 28(1):56-70. DOI: 10.1016/0042-6822(66)90306-0. View

Rowe W, Bau S . Studies of adenovirus SV40 hybrid viruses. II. Defectiveness of the hybrid particles. J Exp Med. 1965; 122(5):955-66. PMC: 2138111. DOI: 10.1084/jem.122.5.955. View

10.

Rowe W . Studies of adenovirus-SV40 hybrid viruses. 3. Transfer of SV40 gene between adenovirus types. Proc Natl Acad Sci U S A. 1965; 54(3):711-7. PMC: 219732. DOI: 10.1073/pnas.54.3.711. View

11.

Rapp F, Butel J, Melnick J . SV40-adenovirus "hybrid" populations: transfer of SV40 determinants from one type of adenovirus to another. Proc Natl Acad Sci U S A. 1965; 54(3):717-24. PMC: 219733. DOI: 10.1073/pnas.54.3.717. View

12.

Boeye A, Melnick J, Rapp F . ADENOVIRUS-SV40 "HYBRIDS": PLAQUE PURIFICATION INTO LINES IN WHICH THE DETERMINANT FOR THE SV40 TUMOR ANTIGEN IS LOST OR RETAINED. Virology. 1965; 26:511-2. DOI: 10.1016/0042-6822(65)90016-4. View

13.

Baum S, Reich P, Hybner C, Rowe W, Weissman S . Biophysical evidence for linkage of adenovirus and SV40 DNA's in adenovirus 7-SV40 hybrid particles. Proc Natl Acad Sci U S A. 1966; 56(5):1509-15. PMC: 220016. DOI: 10.1073/pnas.56.5.1509. View

14.

Rowe W, Baum S . EVIDENCE FOR A POSSIBLE GENETIC HYBRID BETWEEN ADENOVIRUS TYPE 7 AND SV40 VIRUSES. Proc Natl Acad Sci U S A. 1964; 52:1340-7. PMC: 300450. DOI: 10.1073/pnas.52.6.1340. View

15.

Butel J, Melnick J, Rapp F . Detection of biologically active adenovirions unable to plaque in human cells. J Bacteriol. 1966; 92(2):433-8. PMC: 276260. DOI: 10.1128/jb.92.2.433-438.1966. View