Virus-specific Nucleic Acids in SV40-exposed Hamster Embryo Cell Lines: Correlation with S and T Antigens

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1969 Feb 1

PMID 4307716

Citations 19

Authors

M J Levin

M N Oxman

G T DIAMANDOPOULOS

A S Levine

P H Henry

J F ENDERS

Affiliations

Soon will be listed here.

Abstract

A number of homologous SV40-exposed hamster embryonic cell lines were examined for the presence of RNA complementary to SV40 DNA. Only those lines containing the SV40 T antigen were found to have such virus-specific RNA. In lines containing the SV40 S antigen, but not the SV40 T antigen, virus-specific RNA was not detected. These findings suggest that the S antigen is not coded for directly by the SV40 genome.

Citing Articles

Interferon and transcription of early virus-specific RNA in cells infected with simian virus 40.

Oxman M, Levin M Proc Natl Acad Sci U S A. 1971; 68(2):299-302.

PMID: 5277073 PMC: 388922. DOI: 10.1073/pnas.68.2.299.

Studies of nondefective adenovirus 2-simian virus 40 hybrid viruses. Transformation of hamster kidney cells by adenovirus 2 and the nondefective hybrid viruses.

Lewis Jr A, Rabson A, Levine A J Virol. 1974; 13(6):1291-301.

PMID: 4364901 PMC: 355448. DOI: 10.1128/JVI.13.6.1291-1301.1974.

Evidence that the AKR murine-leukemia-virus genome is complete in DNA of the high-virus AKR mouse and incomplete in the DNA of the "virus-negative" NIH mouse.

Chattopadhyay S, Lowy D, Teich N, Levine A, Rowe W Proc Natl Acad Sci U S A. 1974; 71(1):167-71.

PMID: 4359326 PMC: 387958. DOI: 10.1073/pnas.71.1.167.

Control of simian virus 40 gene expression in adenovirus-simian virus 40 hybrid viruses. Synthesis of hybrid adenovirus 2-simian virus 40 RNA molecules in cells infected with a nondefective adenovirus 2-simian virus 40 hybrid virus.

Oxman M, Levin M, Lewis Jr A J Virol. 1974; 13(2):322-30.

PMID: 4359297 PMC: 355300. DOI: 10.1128/JVI.13.2.322-330.1974.

Variants of simian virus 40-transformed 3T3 cells that are resistant to concanavalin A.

Ozanne B J Virol. 1973; 12(1):79-89.

PMID: 4353502 PMC: 355233. DOI: 10.1128/JVI.12.1.79-89.1973.

References

Rowe W, Baum S, Pugh E, HOGGAN M . Studies of adenovirus SV40 hybrid viruses. I. Assay system and further evidence for hybridization. J Exp Med. 1965; 122(5):943-54. PMC: 2138118. DOI: 10.1084/jem.122.5.943. View

Rose J, Reich P, Weissman S . RNA production in adenovirus-infected KB cells. Virology. 1965; 27(4):571-9. DOI: 10.1016/0042-6822(65)90183-2. View

Gillespie D, Spiegelman S . A quantitative assay for DNA-RNA hybrids with DNA immobilized on a membrane. J Mol Biol. 1965; 12(3):829-42. DOI: 10.1016/s0022-2836(65)80331-x. View

Gerber P . Studies on the transfer of subviral infectivity from SV40-induced hamster tumor cells to indicator cells. Virology. 1966; 28(4):501-9. DOI: 10.1016/0042-6822(66)90234-0. View

Fujinaga K, Green M . The mechanism of viral carcinogenesis by DNA mammalian viruses: viral-specific RNA in polyribosomes of adenovirus tumor and transformed cells. Proc Natl Acad Sci U S A. 1966; 55(6):1567-74. PMC: 224360. DOI: 10.1073/pnas.55.6.1567. View

Oxman M, Baron S, Black P, Takemoto K, HABEL K, Rowe W . The effect of interferon on SV-40 T antigen production in SV-40-transformed cells. Virology. 1967; 32(1):122-7. DOI: 10.1016/0042-6822(67)90260-7. View

KLUCHAREVA T, Shachanina K, Belova S, Chibisova V, Deichman G . Use of immunofluorescence for detection of specific membrane antigen in simian virus 40-infected nontransformed cells. J Natl Cancer Inst. 1967; 39(5):825-32. View

Aloni Y, Winocour E, Sachs L . Characterization of the simian virus 40-specific RNA in virus-yielding and transformed cells. J Mol Biol. 1968; 31(3):415-29. DOI: 10.1016/0022-2836(68)90418-x. View

DIAMANDOPOULOS G, Tevethia S, Rapp F, ENDERS J . Development of S and T antigens and oncogenicity in hamster embryonic cell lines exposed to SV40. Virology. 1968; 34(2):331-6. DOI: 10.1016/0042-6822(68)90243-2. View

10.

Anderer F, Koch M, SCHLUMBERGER H . Structure of simian virus 40. 3. Alkaline degradation of the virus particle. Virology. 1968; 34(3):452-8. DOI: 10.1016/0042-6822(68)90065-2. View

11.

Tevethia S, DIAMANDOPOULOS G, Rapp F, ENDERS J . Lack of relationship between virus-specific surface and transplantation antigens in hamster cells transformed by simian papovavirus SV40. J Immunol. 1968; 101(6):1192-8. View

12.

Oda K, DULBECCO R . Regulation of transcription of the SV40 DNA in productively infected and in transformed cells. Proc Natl Acad Sci U S A. 1968; 60(2):525-32. PMC: 225079. DOI: 10.1073/pnas.60.2.525. View

13.

Eagle H . Amino acid metabolism in mammalian cell cultures. Science. 1959; 130(3373):432-7. DOI: 10.1126/science.130.3373.432. View

14.

Scherrer K, Darnell J . Sedimentation characteristics of rapidly labelled RNA from HeLa cells. Biochem Biophys Res Commun. 1962; 7:486-90. DOI: 10.1016/0006-291x(62)90341-8. View

15.

HOPPS H, BERNHEIM B, Nisalak A, Tjio J, SMADEL J . BIOLOGIC CHARACTERISTICS OF A CONTINUOUS KIDNEY CELL LINE DERIVED FROM THE AFRICAN GREEN MONKEY. J Immunol. 1963; 91:416-24. View

16.

Black P, Rowe W . VIRAL STUDIES OF SV40 TUMORIGENESIS IN HAMSTERS. J Natl Cancer Inst. 1964; 32:253-65. View

17.

Pope J, Rowe W . DETECTION OF SPECIFIC ANTIGEN IN SV40-TRANSFORMED CELLS BY IMMUNOFLUORESCENCE. J Exp Med. 1964; 120:121-8. PMC: 2137732. DOI: 10.1084/jem.120.2.121. View

18.

CRAWFORD L, Black P . THE NUCLEIC ACID OF SIMIAN VIRUS 40. Virology. 1964; 24:388-92. DOI: 10.1016/0042-6822(64)90176-x. View

19.

Rapp F, Melnick J, Kitahara T . TUMOR AND VIRUS ANTIGENS OF SIMIAN VIRUS 40: DIFFERENTIAL INHIBITION OF SYNTHESIS BY CYTOSINE ARABINOSIDE. Science. 1965; 147(3658):625-7. DOI: 10.1126/science.147.3658.625. View

20.

KIRBY K . ISOLATION AND CHARACTERIZATION OF RIBOSOMAL RIBONUCLEIC ACID. Biochem J. 1965; 96:266-9. PMC: 1206931. DOI: 10.1042/bj0960266. View