Pituitary-adrenal Influences on Fear Responding

Overview

Journal Science

Specialty Science

Date 1969 Jan 10

PMID 4303023

Citations 7

Authors

J M Weiss

B S McEwen

M T Silva

M F Kalkut

Affiliations

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Abstract

In a passive avoidance situation, hypophysectomized male rats show less fear than normal rats, whereas adrenalectomized rats show greater fear than normals. These results probably occur because hypophysectomized rats lack adrenocorticotrophic hormone, which increases arousal or emotionality, whereas adrenalectomized animals lack certain adrenal steroids, which inhibit excitatory effects. The results indicate that adrenocorticotrophic hormone and certain adrenal steroids have opposite effects in regulating fear-motivated behavior.

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