Benign Lymphoepithelial Lesion (Mikulicz's Disease) of the Salivary Gland: an Ultrastructural Study

Overview

Journal Hum Pathol

Specialty Pathology

Date 1979 Jan 1

PMID 428999

Citations 6

Authors

L B Kahn

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Abstract

An ultrastructural study of a benign lymphoepithelial lesion of the parotid gland demonstrated that the so-called epimyoepithelial cell islands were sharply demarcated from the surrounding parenchyma by a thick basement membrane containing collagen fibers. The hyaline material seen by light microscopy within the islands was ultrastructurally similar in appearance to this delimiting basement membrane. The epithelial cells within the islands were united by well formed desmosomes and many had prominent tonofilament bundles, but myogenic differentiation was not observed. Hydropic degeneration was not seen in these epithelial cells; cells with a perinuclear clear space seen by light microscopy corresponded to large lymphoid cells ultrastructurally.

Citing Articles

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Ultrastructure and three-dimensional imaging of epimyoepithelial islands in benign lymphoepithelial lesions.

Yoshihara T, Morita M, Ishii T Eur Arch Otorhinolaryngol. 1995; 252(2):106-11.

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